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Lypd4 Gene Detail
Summary
  • Symbol
    Lypd4
  • Name
    Ly6/Plaur domain containing 4
  • Synonyms
    4933400F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687054
    NCBI Gene: 232973
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24564044-24569180 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687054
 protein coding gene Chr7:24564044-24569366 (-)
129S1/SvImJ ENSMUSG00200037788
 protein coding gene Chr7:14568083-14573404 (-)
A/J ENSMUSG00195051969
 protein coding gene Chr7:17004711-17010034 (-)
AKR/J ENSMUSG00220042943
 protein coding gene Chr7:27380540-27385861 (+)
BALB/cJ ENSMUSG00180048443
 protein coding gene Chr7:15076688-15082011 (-)
C3H/HeJ ENSMUSG00175051738
 protein coding gene Chr7:16120878-16126197 (-)
C57BL/6NJ ENSMUSG00215054717
 protein coding gene Chr7:14480686-14486007 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029347
 protein coding gene Chr7:24135744-24140897 (-)
CAST/EiJ ENSTCUG00005049573
 protein coding gene Chr7:16179781-16185271 (-)
CBA/J ENSMUSG00210051622
 protein coding gene Chr7:15306604-15311929 (-)
DBA/2J ENSMUSG00185051645
 protein coding gene Chr7:18520334-18525655 (-)
FVB/NJ ENSMUSG00205026937
 protein coding gene Chr7:15317149-15322470 (-)
JF1/MsJ ENSUMUG00000054271
 protein coding gene Chr7:22817685-22823033 (-)
LP/J ENSMUSG00230052564
 protein coding gene Chr7:23794269-23799590 (-)
NOD/ShiLtJ ENSMUSG00190049662
 protein coding gene Chr7:14788792-14794119 (-)
NZO/HlLtJ ENSMUSG00225026008
 protein coding gene Chr7:22462386-22467707 (-)
PWK/PhJ ENSLUMG00010043013
 protein coding gene Chr7:14752330-14757653 (-)
SPRET/EiJ ENSMSPG00010038871
 protein coding gene Chr7:14417727-14422953 (-)
WSB/EiJ ENSIUOG00005051047
 protein coding gene Chr7:9277072-9282383 (-)



Homology
more
  • Human Ortholog
    LYPD4, LY6/PLAUR domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPD4, LY6/PLAUR domain containing 4
  • Synonyms
    SMR
  • Links
    NCBI Gene ID: 147719
    UniProt: Q6UWN0

  • Chr Location
    19q13.2; chr19:41835075-41844871 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired sperm migration in the female genital tract and impaired binding of sperm to the zona pellucida, leading to fertilization failure and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232973 NCBI Gene Model | MGI Sequence Detail 5137 C57BL/6J ±  kb
    transcript NM_001419266 RefSeq | MGI Sequence Detail 1200 C57BL/6  
    polypeptide Q8BVP6 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory