Ifitm6 MGI Mouse Gene Detail - MGI:2686976 - interferon induced transmembrane protein 6

Symbol

Ifitm6
Name

interferon induced transmembrane protein 6
Synonyms

fragilis5

Feature Type

protein coding gene
IDs

MGI:2686976
NCBI Gene: 213002
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:140595725-140596805 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.26 cM
Mapping Data

1 experiment

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686976	protein coding gene	Chr7:140595612-140597837 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033206	protein coding gene	Chr7:146165980-146167060 (-)
A/J	MGP_AJ_G0033188	protein coding gene	Chr7:142003613-142004693 (-)
AKR/J	MGP_AKRJ_G0033120	protein coding gene	Chr7:145905266-145906347 (-)
BALB/cJ	MGP_BALBcJ_G0033189	protein coding gene	Chr7:141740773-141741853 (-)
C3H/HeJ	MGP_C3HHeJ_G0032903	protein coding gene	Chr7:145654829-145655909 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033700	protein coding gene	Chr7:151513743-151514823 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030673	protein coding gene	Chr7:143212927-143214010 (-)
CAST/EiJ	MGP_CASTEiJ_G0032233	protein coding gene	Chr7:137962533-137963613 (-)
CBA/J	MGP_CBAJ_G0032875	protein coding gene	Chr7:156627114-156628194 (-)
DBA/2J	MGP_DBA2J_G0033028	protein coding gene	Chr7:139952143-139953223 (-)
FVB/NJ	MGP_FVBNJ_G0032980	protein coding gene	Chr7:139853750-139854830 (-)
LP/J	MGP_LPJ_G0033122	protein coding gene	Chr7:147666208-147667288 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033013	protein coding gene	Chr7:157307361-157308441 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033720	protein coding gene	Chr7:144883840-144884920 (-)
PWK/PhJ	MGP_PWKPhJ_G0031937	protein coding gene	Chr7:133216151-133217231 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031784	protein coding gene	Chr7:131705177-131706258 (-)
WSB/EiJ	MGP_WSBEiJ_G0032344	protein coding gene	Chr7:145827485-145828565 (-)

Human Ortholog

IFITM3, interferon induced transmembrane protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFITM3, interferon induced transmembrane protein 3
Synonyms

1-8U, DSPA2b, IP15
Links

HGNC:5414

NCBI Gene ID: 10410

UniProt: Q01628
Chr Location

11p15.5; chr11:319676-329475 (-) GRCh38

MGI Vertebrate Homology

Ifitm6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFITM3
Gene Tree

Ifitm6

Diseases

3 with human IFITM1,IFITM3 associations

				Human Disease	Mouse Models
				adenosquamous gallbladder carcinoma IDs adenosquamous gallbladder carcinoma DOID:5627 NCI:C7356 UMLS_CUI:C1333741
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				gallbladder adenocarcinoma IDs gallbladder adenocarcinoma DOID:3500 NCI:C9166 UMLS_CUI:C0279651

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotype references

All Mutations and Alleles

78
Endonuclease-mediated

2
Gene trapped

70
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Ifitm6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

19
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

10
cDNA Data

10
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS21997.1

Ensembl

ENSMUSG00000059108 (Evidence)
NCBI Gene

213002

			Length	Strain/Species	Flank
genomic	213002	NCBI Gene Model \| MGI Sequence Detail	1081	C57BL/6J	± kb
transcript	NM_001436161	RefSeq \| MGI Sequence Detail	851	C57BL/6
polypeptide	NP_001028804	RefSeq \| MGI Sequence Detail	104	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR007593 CD225/Dispanin family

IPR051517 Interferon-induced transmembrane antiviral protein

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 21
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:362502 Lv Y, et al., IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex. Adv Sci (Weinh). 2025 Mar 7;:e2501593

TSS for Ifitm6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75572	Chr7:140597915-140597936 (-)	-1,121 bp
Tssr75571	Chr7:140597504-140597513 (-)	-704 bp
Tssr75570	Chr7:140597465-140597482 (-)	-669 bp
Tssr75569	Chr7:140596857-140596872 (-)	-60 bp
Tssr75568	Chr7:140596811-140596828 (-)	-15 bp
Tssr75567	Chr7:140596751-140596763 (-)	48 bp
Tssr75566	Chr7:140596730-140596744 (-)	68 bp
Tssr75565	Chr7:140596704-140596715 (-)	95 bp
Tssr75564	Chr7:140596689-140596696 (-)	112 bp
Tssr2447	Chr7:140596027-140596039 (-)	772 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24