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Iglon5 Gene Detail
Summary
  • Symbol
    Iglon5
  • Name
    IgLON family member 5
  • Synonyms
    A230106M20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686277
    NCBI Gene: 210094
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43122328-43139499 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686277
 protein coding gene Chr7:43122325-43139635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032128
 protein coding gene Chr7:43486694-43503769 (-)
A/J MGP_AJ_G0032113
 protein coding gene Chr7:42599693-42617054 (-)
AKR/J MGP_AKRJ_G0032043
 protein coding gene Chr7:43969453-43988832 (-)
BALB/cJ MGP_BALBcJ_G0032118
 protein coding gene Chr7:42714582-42731878 (-)
C3H/HeJ MGP_C3HHeJ_G0031834
 protein coding gene Chr7:44470269-44487463 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032602
 protein coding gene Chr7:45682082-45699217 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029625
 protein coding gene Chr7:44720889-44737951 (-)
CAST/EiJ MGP_CASTEiJ_G0031164
 protein coding gene Chr7:35645288-35662054 (-)
CBA/J MGP_CBAJ_G0031803
 protein coding gene Chr7:47125269-47145663 (-)
DBA/2J MGP_DBA2J_G0031952
 protein coding gene Chr7:42399681-42416777 (-)
FVB/NJ MGP_FVBNJ_G0031913
 protein coding gene Chr7:42119222-42136462 (-)
LP/J MGP_LPJ_G0032031
 protein coding gene Chr7:44225312-44243695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031949
 protein coding gene Chr7:46078001-46097641 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032622
 protein coding gene Chr7:43098606-43116477 (-)
PWK/PhJ MGP_PWKPhJ_G0030885
 protein coding gene Chr7:35843267-35861491 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030724
 protein coding gene Chr7:31148523-31165474 (-)
WSB/EiJ MGP_WSBEiJ_G0031278
 protein coding gene Chr7:43641307-43660052 (-)



Homology
more
  • Human Ortholog
    IGLON5, IgLON family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGLON5, IgLON family member 5
  • Links
    NCBI Gene ID: 402665
    neXtProt AC: NX_A6NGN9
    UniProt: A6NGN9

  • Chr Location
    19q13.41; chr19:51311644-51330891 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males show subtle alterations in motor coordination and balance, have depressive-like behavior and excessive nest-building, enlarged seminal vesicle and lymph nodes, and abnormal liver. Females are hyperactive, show enlarged kidney and spleen, and abnormal skin and eye morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    79
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013367 Ensembl Gene Model | MGI Sequence Detail 17172 C57BL/6J ±  kb
    transcript ENSMUST00000107974 Ensembl | MGI Sequence Detail 2622 Not Applicable  
    polypeptide ENSMUSP00000103608 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    • Latest
      J:345884 Landa J, et al., IgLON5 deficiency produces behavioral alterations in a knockout mouse model. Front Immunol. 2024;15:1347948
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory