Neil2 MGI Mouse Gene Detail - MGI:2686058

Symbol

Neil2
Name

nei like 2 (E. coli)
Synonyms

LOC382913, NEH2

Feature Type

protein coding gene
IDs

MGI:2686058
NCBI Gene: 382913
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:63419892-63431305 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.24 cM
Mapping Data

1 experiment

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686058	protein coding gene	Chr14:63419888-63431604 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021458	protein coding gene	Chr14:57673046-57684130 (-)
A/J	MGP_AJ_G0021417	protein coding gene	Chr14:56379771-56391037 (-)
AKR/J	MGP_AKRJ_G0021393	protein coding gene	Chr14:58388983-58404676 (-)
BALB/cJ	MGP_BALBcJ_G0021423	protein coding gene	Chr14:56333617-56344319 (-)
C3H/HeJ	MGP_C3HHeJ_G0021200	protein coding gene	Chr14:58003415-58015427 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021862	protein coding gene	Chr14:60429767-60442052 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019402	protein coding gene	Chr14:54337839-54349484 (-)
CAST/EiJ	MGP_CASTEiJ_G0020717	protein coding gene	Chr14:54457129-54467887 (-)
CBA/J	MGP_CBAJ_G0021167	protein coding gene	Chr14:62222353-62236216 (-)
DBA/2J	MGP_DBA2J_G0021290	protein coding gene	Chr14:56062142-56073555 (-)
FVB/NJ	MGP_FVBNJ_G0021269	protein coding gene	Chr14:55446723-55458993 (-)
LP/J	MGP_LPJ_G0021365	protein coding gene	Chr14:58706081-58716553 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021298	protein coding gene	Chr14:61486385-61499090 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021885	protein coding gene	Chr14:57530779-57543210 (-)
PWK/PhJ	MGP_PWKPhJ_G0020461	protein coding gene	Chr14:52722553-52732403 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020294	protein coding gene	Chr14:53503775-53514294 (-)
WSB/EiJ	MGP_WSBEiJ_G0020770	protein coding gene	Chr14:57856045-57869915 (-)

Human Ortholog

NEIL2, nei like DNA glycosylase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEIL2, nei like DNA glycosylase 2
Synonyms

NEH2, NEI2
Links

HGNC:18956

NCBI Gene ID: 252969

neXtProt AC: NX_Q969S2

UniProt: Q969S2
Chr Location

8p23.1; chr8:11769639-11787345 (+) GRCh38

MGI Vertebrate Homology

Neil2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NEIL2
Gene Tree

Neil2

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Neil2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased age-related DNA damage, loss of telomeres and increased induced lung inflammation.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase neil2

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All Sequences

52
RefSeq

14
UniProt

4
CCDS

CCDS36949.1

Ensembl

ENSMUSG00000035121 (Evidence)
NCBI Gene

382913

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035121	Ensembl Gene Model \| MGI Sequence Detail	11414	C57BL/6J	± kb
transcript	ENSMUST00000038229	Ensembl \| MGI Sequence Detail	1932	Not Applicable
polypeptide	ENSMUSP00000045200	Ensembl \| MGI Sequence Detail	329	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011123 endonuclease 8-like 2

(term hierarchy)
EC

3.2.2.-, 4.2.99.18
InterPro Domains

IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding

IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain

IPR010979 Small ribosomal subunit protein uS13-like, H2TH

IPR000214 Zinc finger, DNA glycosylase/AP lyase-type

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 7
Earliest

J:96949 Conlon KA, et al., The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst). 2005 Apr 4;4(4):419-31
Latest

J:340875 Zhou Z, et al., Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. J Ovarian Res. 2023 Aug 10;16(1):160

TSS for Neil2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129166	Chr14:63430937-63430957 (-)	358 bp
Tssr129165	Chr14:63429382-63429386 (-)	1,921 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23