Slc22a14 MGI Mouse Gene Detail - MGI:2685974 - solute carrier family 22 (organic cation transporter), member 14

Symbol

Slc22a14
Name

solute carrier family 22 (organic cation transporter), member 14
Synonyms

LOC382113

Feature Type

protein coding gene
IDs

MGI:2685974
NCBI Gene: 382113
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:118998523-119019473 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.33 cM
Mapping Data

1 experiment

SNPs within 2kb

667 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685974	protein coding gene	Chr9:118998521-119019496 (-)
129S1/SvImJ	ENSMUSG00200028238	protein coding gene	Chr9:116117376-116138330 (-)
A/J	ENSMUSG00195026659	protein coding gene	Chr9:115298879-115320180 (-)
AKR/J	ENSMUSG00220019038	protein coding gene	Chr9:115756976-115777971 (-)
BALB/cJ	ENSMUSG00180028801	protein coding gene	Chr9:115836239-115857538 (-)
C3H/HeJ	ENSMUSG00175018479	protein coding gene	Chr9:116079546-116100843 (-)
C57BL/6NJ	ENSMUSG00215026373	protein coding gene	Chr9:115950615-115971574 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032795	protein coding gene	Chr9:114578936-114784415 (-)
CAST/EiJ	ENSTCUG00005015803	protein coding gene	Chr9:115711095-115731844 (-)
CBA/J	ENSMUSG00210040151	protein coding gene	Chr9:115795834-115816786 (-)
DBA/2J	ENSMUSG00185015739	protein coding gene	Chr9:116130051-116151009 (-)
FVB/NJ	ENSMUSG00205026736	protein coding gene	Chr9:115967732-115989037 (-)
JF1/MsJ	ENSUMUG00000024830	protein coding gene	Chr9:115988906-116010209 (-)
LP/J	ENSMUSG00230036526	protein coding gene	Chr9:116245749-116266703 (-)
NOD/ShiLtJ	ENSMUSG00190012911	protein coding gene	Chr9:115729139-115750093 (-)
NZO/HlLtJ	ENSMUSG00225022622	protein coding gene	Chr9:116512371-116533323 (-)
PWK/PhJ	ENSLUMG00010031432	protein coding gene	Chr9:115890683-115912016 (-)
SPRET/EiJ	ENSMSPG00010020597	protein coding gene	Chr9:117591373-117613378 (-)
WSB/EiJ	ENSIUOG00005019771	protein coding gene	Chr9:115182464-115203416 (-)

Human Ortholog

SLC22A14, solute carrier family 22 member 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A14, solute carrier family 22 member 14
Synonyms

OCTL2, OCTL4, ORCTL4
Links

HGNC:8495

NCBI Gene ID: 9389

UniProt: Q9Y267
Chr Location

3p22.2; chr3:38278832-38318575 (+) GRCh38

MGI Vertebrate Homology

Slc22a14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A14
Gene Tree

Slc22a14

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Slc22a14
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show severe male infertility, asthenozoospermia, impaired sperm capacitation with intracellular pH dysregulation, decreased in vitro fertilization, abnormal sperm flagellar bending caused by osmotic cell swelling, and structural defects in the annulus.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

10
UniProt

3
CCDS

CCDS23609.1

Ensembl

ENSMUSG00000070280 (Evidence)
NCBI Gene

382113

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070280	Ensembl Gene Model \| MGI Sequence Detail	20951	C57BL/6J	± kb
transcript	ENSMUST00000093775	Ensembl \| MGI Sequence Detail	2213	Not Applicable
polypeptide	ENSMUSP00000091289	Ensembl \| MGI Sequence Detail	629	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032198 solute carrier family 22 member 14

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily
GlyGen

Q497L9 4 sites

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 1

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 16
Earliest

J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
Latest

J:322731 Ito M, et al., Dysregulation of intracellular pH is a cause of impaired capacitation in Slc22a14-deficient mice. Reproduction. 2021 Dec 13;163(1):23-32

TSS for Slc22a14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91975	Chr9:119019480-119019486 (-)	-10 bp
Tssr91974	Chr9:119019449-119019476 (-)	10 bp
Tssr91973	Chr9:119019431-119019440 (-)	37 bp
Tssr91972	Chr9:119019379-119019384 (-)	91 bp
Tssr91971	Chr9:119019349-119019356 (-)	120 bp
Tssr91970	Chr9:119019331-119019332 (-)	141 bp
Tssr91969	Chr9:119019320-119019324 (-)	151 bp
Tssr91968	Chr9:119019299-119019302 (-)	172 bp
Tssr91967	Chr9:119013192-119013219 (-)	6,267 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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