About   Help   FAQ
Zbtb2 Gene Detail
Summary
  • Symbol
    Zbtb2
  • Name
    zinc finger and BTB domain containing 2
  • Synonyms
    LOC381990
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685949
    NCBI Gene: 381990
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:4317075-4338108 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    586 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685949
 protein coding gene Chr10:4317074-4353114 (-)
129S1/SvImJ ENSMUSG00200009055
 protein coding gene Chr10:1282705-1303707 (-)
A/J ENSMUSG00195008437
 protein coding gene Chr10:1257753-1278754 (-)
AKR/J ENSMUSG00220007047
 protein coding gene Chr10:1295938-1316938 (-)
BALB/cJ ENSMUSG00180020266
 protein coding gene Chr10:1351980-1372976 (-)
C3H/HeJ ENSMUSG00175011880
 protein coding gene Chr10:1315656-1336652 (-)
C57BL/6NJ ENSMUSG00215004571
 protein coding gene Chr10:1252720-1273775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015082
 protein coding gene Chr10:1115643-1135710 (-)
CAST/EiJ ENSTCUG00005017856
 protein coding gene Chr10:1341207-1362045 (-)
CBA/J ENSMUSG00210012392
 protein coding gene Chr10:1263958-1284957 (-)
DBA/2J ENSMUSG00185009477
 protein coding gene Chr10:1322086-1343079 (-)
FVB/NJ ENSMUSG00205007157
 protein coding gene Chr10:1303268-1324259 (-)
JF1/MsJ ENSUMUG00000026680
 protein coding gene Chr10:1446584-1467531 (-)
LP/J ENSMUSG00230016391
 protein coding gene Chr10:2951353-2972344 (-)
NOD/ShiLtJ ENSMUSG00190024158
 protein coding gene Chr10:1258027-1278830 (-)
NZO/HlLtJ ENSMUSG00225013627
 protein coding gene Chr10:7436150-7457123 (-)
PWK/PhJ ENSLUMG00010020193
 protein coding gene Chr10:1294216-1315069 (-)
SPRET/EiJ ENSMSPG00010006729
 protein coding gene Chr10:1484132-1504997 (-)
WSB/EiJ ENSIUOG00005013570
 protein coding gene Chr10:1300392-1321433 (-)



Homology
more
  • Human Ortholog
    ZBTB2, zinc finger and BTB domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB2, zinc finger and BTB domain containing 2
  • Synonyms
    ZNF437
  • Links
    NCBI Gene ID: 57621
    UniProt: Q8N680

  • Chr Location
    6q25.1; chr6:151364105-151391696 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    53
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075327 Ensembl Gene Model | MGI Sequence Detail 21034 C57BL/6J ±  kb
transcript ENSMUST00000100077 Ensembl | MGI Sequence Detail 3086 Not Applicable  
polypeptide ENSMUSP00000097655 Ensembl | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 53
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:363178 Ren AJ, et al., ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban. Circ Res. 2024 Feb 2;134(3):252-265
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory