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Sbk2 Gene Detail
Summary
  • Symbol
    Sbk2
  • Name
    SH3-binding domain kinase family, member 2
  • Synonyms
    LOC381836
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685925
    NCBI Gene: 381836
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4959133-4967405 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685925
 protein coding gene Chr7:4943511-4967405 (-)
129S1/SvImJ ENSMUSG00200040270
 protein coding gene Chr7:1673948-1697727 (-)
A/J ENSMUSG00195050451
 protein coding gene Chr7:1664779-1688547 (-)
AKR/J ENSMUSG00220022789
 protein coding gene Chr7:2406677-2430458 (+)
BALB/cJ ENSMUSG00180041838
 protein coding gene Chr7:1619980-1643759 (-)
C3H/HeJ ENSMUSG00175043222
 protein coding gene Chr7:1627654-1651443 (-)
C57BL/6NJ ENSMUSG00215041483
 protein coding gene Chr7:1666325-1690227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029138
 protein coding gene Chr7:1634848-1643503 (-)
CAST/EiJ ENSTCUG00005023474
 protein coding gene Chr7:1837127-1861210 (-)
CBA/J ENSMUSG00210040667
 protein coding gene Chr7:1626121-1649902 (-)
DBA/2J ENSMUSG00185042533
 protein coding gene Chr7:1808567-1832348 (-)
FVB/NJ ENSMUSG00205043754
 protein coding gene Chr7:1606731-1630510 (-)
JF1/MsJ ENSUMUG00000029577
 protein coding gene Chr7:1875672-1899219 (-)
LP/J ENSMUSG00230037685
 protein coding gene Chr7:4819403-4843179 (-)
NOD/ShiLtJ ENSMUSG00190042019
 protein coding gene Chr7:1698556-1722341 (-)
NZO/HlLtJ ENSMUSG00225020164
 protein coding gene Chr7:2732621-2756476 (-)
PWK/PhJ ENSLUMG00010044056
 protein coding gene Chr7:5388307-5411819 (-)
SPRET/EiJ ENSMSPG00010045966
 protein coding gene Chr7:1815183-1822577 (-)
WSB/EiJ ENSIUOG00005051287
 protein coding gene Chr7:1626560-1650381 (-)



Homology
more
  • Human Ortholog
    SBK2, SH3 domain binding kinase family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SBK2, SH3 domain binding kinase family member 2
  • Synonyms
    SGK069
  • Links
    NCBI Gene ID: 646643
    UniProt: P0C263

  • Chr Location
    19q13.42; chr19:55528609-55537143 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381836 NCBI Gene Model | MGI Sequence Detail 8273 C57BL/6J ±  kb
    transcript NM_001146329 RefSeq | MGI Sequence Detail 2144 C57BL/6  
    polypeptide P0C5K1 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 20
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory