Heca MGI Mouse Gene Detail - MGI:2685715 - hdc homolog, cell cycle regulator

Symbol

Heca
Name

hdc homolog, cell cycle regulator
Synonyms

LOC380629

Feature Type

protein coding gene
IDs

MGI:2685715
NCBI Gene: 380629
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:17774788-17823785 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 7.31 cM
Mapping Data

2 experiments

SNPs within 2kb

262 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685715	protein coding gene	Chr10:17744360-17823815 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017033	protein coding gene	Chr10:15557540-15603305 (-)
A/J	MGP_AJ_G0017011	protein coding gene	Chr10:14950997-14996983 (-)
AKR/J	MGP_AKRJ_G0016975	protein coding gene	Chr10:15188014-15239437 (-)
BALB/cJ	MGP_BALBcJ_G0016969	protein coding gene	Chr10:15029466-15074583 (-)
C3H/HeJ	MGP_C3HHeJ_G0016794	protein coding gene	Chr10:15519024-15575284 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017431	protein coding gene	Chr10:15939174-15988494 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015136	protein coding gene	Chr10:13874250-13921910 (-)
CAST/EiJ	MGP_CASTEiJ_G0016376	protein coding gene	Chr10:15320210-15369984 (-)
CBA/J	MGP_CBAJ_G0016766	protein coding gene	Chr10:16648888-16704753 (-)
DBA/2J	MGP_DBA2J_G0016874	protein coding gene	Chr10:14848019-14896030 (-)
FVB/NJ	MGP_FVBNJ_G0016869	protein coding gene	Chr10:14620114-14667401 (-)
LP/J	MGP_LPJ_G0016949	protein coding gene	Chr10:15371513-15422317 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016899	protein coding gene	Chr10:17008326-17058631 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017469	protein coding gene	Chr10:15173775-15224835 (-)
PWK/PhJ	MGP_PWKPhJ_G0016161	protein coding gene	Chr10:14671680-14719292 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015944	protein coding gene	Chr10:15322705-15372757 (-)
WSB/EiJ	MGP_WSBEiJ_G0016438	protein coding gene	Chr10:15241202-15289075 (-)

Human Ortholog

HECA, hdc homolog, cell cycle regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HECA, hdc homolog, cell cycle regulator
Synonyms

dJ225E12.1, HDC, HDCL, HHDC
Links

HGNC:21041

NCBI Gene ID: 51696

neXtProt AC: NX_Q9UBI9

UniProt: Q9UBI9
Chr Location

6q24.1; chr6:139135080-139180802 (+) GRCh38

Alliance of Genome Resources

Heca stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HECA
Gene Tree

Heca

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Heca
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase heca

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Heca interacts with 260 markers (Mir1a-1, Mir1a-2, Mir10a, ...) View All

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS23709.1

Ensembl

ENSMUSG00000039879 (Evidence)
NCBI Gene

380629

			Length	Strain/Species	Flank
genomic	380629	NCBI Gene Model \| MGI Sequence Detail	48998	C57BL/6J	± kb
transcript	NM_001033432	RefSeq \| MGI Sequence Detail	5061	C57BL/6
polypeptide	NP_001028604	RefSeq \| MGI Sequence Detail	544	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR031947 Headcase, middle domain

IPR026066 Headcase protein

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All nucleic 7

cDNA 7

Microarray probesets 4

Summaries

All 25

Gene Ontology 1

Phenotypes 7
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Heca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96823	Chr10:17823745-17823846 (-)	-11 bp
Tssr96822	Chr10:17820097-17820102 (-)	3,685 bp
Tssr96821	Chr10:17800165-17800167 (-)	23,619 bp
Tssr96820	Chr10:17795942-17795957 (-)	27,835 bp
Tssr96819	Chr10:17795841-17795844 (-)	27,942 bp
Tssr96818	Chr10:17795799-17795804 (-)	27,983 bp
Tssr96817	Chr10:17795785-17795790 (-)	27,997 bp
Tssr3144	Chr10:17795776-17795779 (-)	28,007 bp
Tssr96816	Chr10:17788193-17788196 (-)	35,590 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/21/2023 MGI 6.22