Frem3 MGI Mouse Gene Detail - MGI:2685641 - Fras1 related extracellular matrix protein 3

Symbol

Frem3
Name

Fras1 related extracellular matrix protein 3
Synonyms

LOC333315

Feature Type

protein coding gene
IDs

MGI:2685641
NCBI Gene: 333315
Alliance

genome feature page

Sequence Map

Chr8:81337709-81421985 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 38.35 cM
Mapping Data

1 experiment

SNPs within 2kb

2447 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685641	protein coding gene	Chr8:81337668-81422186 (+)
129S1/SvImJ	ENSMUSG00200022476	protein coding gene	Chr8:75701432-75786228 (+)
A/J	ENSMUSG00195015982	protein coding gene	Chr8:76048783-76133605 (+)
AKR/J	ENSMUSG00220021106	protein coding gene	Chr8:76140023-76219207 (+)
BALB/cJ	ENSMUSG00180016865	protein coding gene	Chr8:75899838-75984653 (+)
C3H/HeJ	ENSMUSG00175009811	protein coding gene	Chr8:75978935-76063727 (+)
C57BL/6NJ	ENSMUSG00215012994	protein coding gene	Chr8:75615540-75700333 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031255	protein coding gene	Chr8:72114681-72188748 (+)
CAST/EiJ	ENSTCUG00005032130	protein coding gene	Chr8:75535799-75608892 (+)
CBA/J	ENSMUSG00210019917	protein coding gene	Chr8:75971043-76055837 (+)
DBA/2J	ENSMUSG00185034151	protein coding gene	Chr8:82080234-82165036 (+)
FVB/NJ	ENSMUSG00205027643	protein coding gene	Chr8:75046657-75131453 (+)
JF1/MsJ	ENSUMUG00000025906	protein coding gene	Chr8:84401121-84473737 (+)
LP/J	ENSMUSG00230026918	protein coding gene	Chr8:85698447-85783251 (+)
NOD/ShiLtJ	ENSMUSG00190021960	protein coding gene	Chr8:76022791-76101975 (+)
NZO/HlLtJ	ENSMUSG00225022935	protein coding gene	Chr8:89085029-89164265 (+)
PWK/PhJ	ENSLUMG00010026551	protein coding gene	Chr8:75813537-75884034 (+)
SPRET/EiJ	ENSMSPG00010021632	protein coding gene	Chr8:77610845-77701569 (+)
WSB/EiJ	ENSIUOG00005014892	protein coding gene	Chr8:76785592-76864717 (+)

Human Ortholog

FREM3, FRAS1 related extracellular matrix 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FREM3, FRAS1 related extracellular matrix 3
Links

HGNC:25172

NCBI Gene ID: 166752

UniProt: P0C091
Chr Location

4q31.21; chr4:143577302-143700675 (-) GRCh38

MGI Vertebrate Homology

Frem3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FREM3
Gene Tree

Frem3

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
37 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Genomic Mutations

2 involving Frem3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

103 strains or lines available

Mice homozygous for a null allele exhibit no embryonic lethality and normal fertility, size, and no apparent Fraser syndrome- or MOTA/BNAR-like developmental defects.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

695
Tissues

78
cDNA Data

1
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase frem3

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All Sequences

29
RefSeq

3
UniProt

2
CCDS

CCDS52606.1

Ensembl

ENSMUSG00000042353 (Evidence)
NCBI Gene

333315

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042353	Ensembl Gene Model \| MGI Sequence Detail	84277	C57BL/6J	± kb
transcript	ENSMUST00000039695	Ensembl \| MGI Sequence Detail	6384	Not Applicable
polypeptide	ENSMUSP00000038015	Ensembl \| MGI Sequence Detail	2127	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007658 FRAS1-related extracellular matrix protein 3

(term hierarchy)
InterPro Domains

IPR038081 CalX-like domain superfamily

IPR039005 CSPG repeat

IPR051561 FRAS1-related extracellular matrix

IPR045658 FRAS1-related extracellular matrix protein, N-terminal domain

IPR003644 Na-Ca exchanger/integrin-beta4
GlyGen

Q5H8B9 9 sites, 3 N-linked glycans (5 sites)

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All nucleic 3

cDNA 1

Primer pair 2

Antibodies 2

Microarray probesets 1

Summaries

All 59

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 37
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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