Kcnk18 MGI Mouse Gene Detail - MGI:2685627 - potassium channel, subfamily K, member 18

Symbol

Kcnk18
Name

potassium channel, subfamily K, member 18
Synonyms

LOC332396, Tresk, Tresk-2, Trik

Feature Type

protein coding gene
IDs

MGI:2685627
NCBI Gene: 332396
Alliance

gene page

Sequence Map

Chr19:59208080-59225802 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 54.63 cM
Mapping Data

1 experiment

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685627	protein coding gene	Chr19:59207646-59225806 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025286	protein coding gene	Chr19:59732090-59747778 (+)
A/J	MGP_AJ_G0025262	protein coding gene	Chr19:56817121-56831775 (+)
AKR/J	MGP_AKRJ_G0025231	protein coding gene	Chr19:58580117-58594826 (+)
BALB/cJ	MGP_BALBcJ_G0025257	protein coding gene	Chr19:56882605-56897254 (+)
C3H/HeJ	MGP_C3HHeJ_G0025017	protein coding gene	Chr19:58837683-58854008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025700	protein coding gene	Chr19:61174913-61192656 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023112	protein coding gene	Chr19:55694262-55710800 (+)
CAST/EiJ	MGP_CASTEiJ_G0024482	protein coding gene	Chr19:58929983-58944638 (+)
CBA/J	MGP_CBAJ_G0024997	protein coding gene	Chr19:64163269-64182327 (+)
DBA/2J	MGP_DBA2J_G0025129	protein coding gene	Chr19:56576293-56593944 (+)
FVB/NJ	MGP_FVBNJ_G0025090	protein coding gene	Chr19:56304335-56318993 (+)
LP/J	MGP_LPJ_G0025215	protein coding gene	Chr19:59609322-59623966 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025123	protein coding gene	Chr19:63380208-63397926 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025758	protein coding gene	Chr19:58826021-58843908 (+)
PWK/PhJ	MGP_PWKPhJ_G0024230	protein coding gene	Chr19:56589090-56591635 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024033	protein coding gene	Chr19:57477521-57496789 (+)
WSB/EiJ	MGP_WSBEiJ_G0024552	protein coding gene	Chr19:58937996-58952649 (+)

Human Ortholog

KCNK18, potassium two pore domain channel subfamily K member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNK18, potassium two pore domain channel subfamily K member 18
Synonyms

K2p18.1, MGR13, TRESK, TRESK2, TRESK-2, TRIK
Links

HGNC:19439

NCBI Gene ID: 338567

neXtProt AC: NX_Q7Z418

UniProt: Q7Z418
Chr Location

10q25.3; chr10:117197489-117210299 (+) GRCh38

MGI Vertebrate Homology

Kcnk18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNK18
Gene Tree

Kcnk18

Diseases

1 with human KCNK18 associations

				Human Disease	Mouse Models
				migraine IDs migraine DOID:6364 DOID:12437 ICD10CM:G43 ICD9CM:346 ICD9CM:346.9 MESH:D008881 NCI:C89715 OMIM:157300 UMLS_CUI:C0042331 UMLS_CUI:C0149931

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit altered potassium conductance and neuron electrophysiology.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

8
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN kcnk18

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS29934.1

Ensembl

ENSMUSG00000040901 (Evidence)
NCBI Gene

332396

			Length	Strain/Species	Flank
genomic	332396	NCBI Gene Model \| MGI Sequence Detail	17723	C57BL/6J	± kb
transcript	NM_207261	RefSeq \| MGI Sequence Detail	3032	C57BL/6
polypeptide	Q6VV64	UniProt \| EBI \| MGI Sequence Detail	394	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009264 potassium channel subfamily K member 18

(term hierarchy)
InterPro Domains

IPR013099 Potassium channel domain

IPR003280 Two pore domain potassium channel

IPR003092 Two pore domain potassium channel, TASK family

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All nucleic 12

Genomic 1

cDNA 11

Microarray probesets 1

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 19
Earliest

J:90661 Czirjak G, et al., The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J Biol Chem. 2004 Apr 30;279(18):18550-8
Latest

J:329126 Huang W, et al., TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. Cell Rep. 2021 Jul 20;36(3):109404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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