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Samd3 Gene Detail
Summary
  • Symbol
    Samd3
  • Name
    sterile alpha motif domain containing 3
  • Synonyms
    LOC268288
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685469
    NCBI Gene: 268288
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:26105605-26148070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 13.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685469
 protein coding gene Chr10:26105465-26148814 (+)
129S1/SvImJ ENSMUSG00200008604
 protein coding gene Chr10:22920615-22963146 (+)
A/J ENSMUSG00195013886
 protein coding gene Chr10:23222915-23265447 (+)
AKR/J ENSMUSG00220010727
 protein coding gene Chr10:22903351-22945883 (+)
BALB/cJ ENSMUSG00180016550
 protein coding gene Chr10:23351729-23394257 (+)
C3H/HeJ ENSMUSG00175023439
 protein coding gene Chr10:23019962-23062501 (+)
C57BL/6NJ ENSMUSG00215010154
 protein coding gene Chr10:22897112-22939663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015198
 protein coding gene Chr10:22178726-22237545 (+)
CAST/EiJ ENSTCUG00005013261
 protein coding gene Chr10:22680639-22722607 (+)
CBA/J ENSMUSG00210023073
 protein coding gene Chr10:23011918-23054449 (+)
DBA/2J ENSMUSG00185006612
 protein coding gene Chr10:23183928-23226462 (+)
FVB/NJ ENSMUSG00205009328
 protein coding gene Chr10:23158438-23200969 (+)
JF1/MsJ ENSUMUG00000016705
 protein coding gene Chr10:22949371-22991512 (+)
LP/J ENSMUSG00230011015
 protein coding gene Chr10:24955116-24997639 (+)
NOD/ShiLtJ ENSMUSG00190015221
 protein coding gene Chr10:23309708-23352238 (+)
NZO/HlLtJ ENSMUSG00225029707
 protein coding gene Chr10:29213978-29256504 (+)
PWK/PhJ ENSLUMG00010010043
 protein coding gene Chr10:22844234-22886925 (+)
SPRET/EiJ ENSMSPG00010014146
 protein coding gene Chr10:23609445-23656133 (+)
WSB/EiJ ENSIUOG00005029223
 protein coding gene Chr10:22597622-22639616 (+)



Homology
more
  • Human Ortholog
    SAMD3, sterile alpha motif domain containing 3
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD3, sterile alpha motif domain containing 3
  • Links
    NCBI Gene ID: 154075
    UniProt: Q8N6K7

  • Chr Location
    6q23.1; chr6:130142752-130365868 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased memory CD8+ cells and normal response to acute Vaccinia virus or chronic Lymphocytic choriomeningitis virus.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    95
  • cDNA Data
    7
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051354 Ensembl Gene Model | MGI Sequence Detail 42466 C57BL/6J ±  kb
transcript ENSMUST00000220219 Ensembl | MGI Sequence Detail 1744 Not Applicable  
polypeptide ENSMUSP00000151558 Ensembl | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000029743 sterile alpha motif domain-containing protein 3
    (term hierarchy)
  • InterPro Domains
    IPR042813 SAMD3, SAM domain
    IPR001660 Sterile alpha motif domain
    IPR042812 Sterile alpha motif domain-containing protein 3
    IPR063355 Sterile alpha motif domain-containing protein 3, helical domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 7
    Primer pair 2
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory