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Rtl9 Gene Detail
Summary
  • Symbol
    Rtl9
  • Name
    retrotransposon Gag like 9
  • Synonyms
    Mar9, Mart9, Rgag1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685231
    NCBI Gene: 209540
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:141876886-141887293 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 64.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685231
protein coding gene ChrX:141841655-141888326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036153
protein coding gene ChrX:140634655-140639354 (+)
A/J MGP_AJ_G0036130
protein coding gene ChrX:140012265-140016934 (+)
AKR/J MGP_AKRJ_G0036056
protein coding gene ChrX:144505524-144510235 (+)
BALB/cJ MGP_BALBcJ_G0036121
protein coding gene ChrX:138235104-138239815 (+)
C3H/HeJ MGP_C3HHeJ_G0035829
protein coding gene ChrX:140735287-140739990 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036644
protein coding gene ChrX:144636731-144641434 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033468
protein coding gene ChrX:131544825-131549484 (+)
CAST/EiJ MGP_CASTEiJ_G0035120
protein coding gene ChrX:121436004-121440681 (+)
CBA/J MGP_CBAJ_G0035806
protein coding gene ChrX:149180765-149185468 (+)
DBA/2J MGP_DBA2J_G0035964
protein coding gene ChrX:139093724-139098427 (+)
FVB/NJ MGP_FVBNJ_G0035898
protein coding gene ChrX:138296814-138301527 (+)
LP/J MGP_LPJ_G0036055
protein coding gene ChrX:141591654-141596357 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035934
protein coding gene ChrX:156809262-156813959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036681
protein coding gene ChrX:139934972-139939675 (+)
PWK/PhJ MGP_PWKPhJ_G0034814
protein coding gene ChrX:118237995-118242749 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034639
protein coding gene ChrX:121968382-121973029 (+)
WSB/EiJ MGP_WSBEiJ_G0035255
protein coding gene ChrX:138308600-138313347 (+)



Homology
more
  • Human Ortholog
    RTL9, retrotransposon Gag like 9
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTL9, retrotransposon Gag like 9
  • Synonyms
    MAR9, MART9, RGAG1, SIRH10
  • Links
    NCBI Gene ID: 57529
    neXtProt AC: NX_Q8NET4
    UniProt: Q8NET4

  • Chr Location
    Xq23; chrX:110358848-110456334 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice lacking the C-terminal retroviral GAG-like region show impaired innate antifungal immunity showing loss of fungal zymosan degradation in microglial lysosomes.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000085584 Ensembl Gene Model | MGI Sequence Detail 10408 C57BL/6J ±  kb
transcript ENSMUST00000165829 Ensembl | MGI Sequence Detail 4333 Not Applicable  
polypeptide ENSMUSP00000128287 Ensembl | MGI Sequence Detail 1367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Phenotypes 1
  • Earliest
    J:96508 Brandt J, et al., Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005 Jan 17;345(1):101-11
  • Latest
    J:343808 Ishino F, et al., Retrovirus-Derived RTL9 Plays an Important Role in Innate Antifungal Immunity in the Eutherian Brain. Int J Mol Sci. 2023 Oct 4;24(19)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
02/13/2024
MGI 6.23
The Jackson Laboratory