Gpr174 MGI Mouse Gene Detail - MGI:2685222 - G protein-coupled receptor 174

Symbol

Gpr174
Name

G protein-coupled receptor 174
Synonyms

LOC213439

Feature Type

protein coding gene
IDs

MGI:2685222
NCBI Gene: 213439
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:106299484-106340375 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.48 cM
Mapping Data

1 experiment

SNPs within 2kb

94 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685222	protein coding gene	ChrX:106299484-106340377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036013	protein coding gene	ChrX:104089775-104132442 (+)
A/J	MGP_AJ_G0035992	protein coding gene	ChrX:103922924-103965017 (+)
AKR/J	MGP_AKRJ_G0035911	protein coding gene	ChrX:107189646-107232277 (+)
BALB/cJ	MGP_BALBcJ_G0035983	protein coding gene	ChrX:102675335-102718164 (+)
C3H/HeJ	MGP_C3HHeJ_G0035689	protein coding gene	ChrX:104556090-104603937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036509	protein coding gene	ChrX:107103079-107147901 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033337	protein coding gene	ChrX:101222906-101255400 (+)
CAST/EiJ	MGP_CASTEiJ_G0034976	protein coding gene	ChrX:88650522-88689977 (+)
CBA/J	MGP_CBAJ_G0035665	protein coding gene	ChrX:110438159-110481697 (+)
DBA/2J	MGP_DBA2J_G0035819	protein coding gene	ChrX:103152336-103191967 (+)
FVB/NJ	MGP_FVBNJ_G0035759	protein coding gene	ChrX:102491713-102532333 (+)
LP/J	MGP_LPJ_G0035911	protein coding gene	ChrX:105037059-105084916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035790	protein coding gene	ChrX:115214038-115269784 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036536	protein coding gene	ChrX:103665480-103706814 (+)
PWK/PhJ	MGP_PWKPhJ_G0034672	protein coding gene	ChrX:86193953-86234274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034501	protein coding gene	ChrX:89448844-89489299 (+)
WSB/EiJ	MGP_WSBEiJ_G0035114	protein coding gene	ChrX:102409198-102453516 (+)

Human Ortholog

GPR174, G protein-coupled receptor 174

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR174, G protein-coupled receptor 174
Synonyms

FKSG79, GPCR17, LPS3, LYPSR3
Links

HGNC:30245

NCBI Gene ID: 84636

neXtProt AC: NX_Q9BXC1

UniProt: Q9BXC1
Chr Location

Xq21.1; chrX:79144688-79175318 (+) GRCh38

MGI Vertebrate Homology

Gpr174 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR174
Gene Tree

Gpr174

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Find Mice (IMSR)

5 strains or lines available

Male mice hemizygous for a knock-out allele exhibit abnormal T cell proliferation, abnormal regulatory T cell physiology and decreased susceptibility to EAE.

less

All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

52
RefSeq

10
UniProt

1
CCDS

CCDS30348.1

Ensembl

ENSMUSG00000073008 (Evidence)
NCBI Gene

213439

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073008	Ensembl Gene Model \| MGI Sequence Detail	40892	C57BL/6J	± kb
transcript	ENSMUST00000117310	Ensembl \| MGI Sequence Detail	3536	Not Applicable
polypeptide	ENSMUSP00000112808	Ensembl \| MGI Sequence Detail	335	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000001640 probable G-protein coupled receptor 174

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR047836 G protein-coupled receptor 174, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

less

All nucleic 15

cDNA 15

Microarray probesets 4

Summaries

All 31

Gene Ontology 5

Phenotypes 6
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:332042 Liu J, et al., GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Nat Commun. 2022 Dec 6;13(1):7519

TSS for Gpr174:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161822	ChrX:106299310-106299320 (+)	-169 bp
Tssr161823	ChrX:106299378-106299388 (+)	-101 bp
Tssr161824	ChrX:106299637-106299670 (+)	170 bp
Tssr161825	ChrX:106299672-106299693 (+)	199 bp
Tssr161826	ChrX:106299762-106299773 (+)	284 bp
Tssr161827	ChrX:106299778-106299779 (+)	295 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23