Tm9sf5 MGI Mouse Gene Detail - MGI:2685210 - transmembrane 9 superfamily member 5

Symbol

Tm9sf5
Name

transmembrane 9 superfamily member 5
Synonyms

Gm364, LOC245423

Feature Type

protein coding gene
IDs

MGI:2685210
NCBI Gene: 245423
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:56454514-56534127 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 31.71 cM
Mapping Data

1 experiment

SNPs within 2kb

1938 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685210	protein coding gene	ChrX:56446127-56534133 (+)
129S1/SvImJ	ENSMUSG00200037320	protein coding gene	ChrX:38781321-38860988 (+)
A/J	ENSMUSG00195009134	protein coding gene	ChrX:42215879-42295519 (+)
AKR/J	ENSMUSG00220038135	protein coding gene	ChrX:38107076-38186722 (+)
BALB/cJ	ENSMUSG00180033113	protein coding gene	ChrX:38848157-38927782 (+)
C3H/HeJ	ENSMUSG00175041069	protein coding gene	ChrX:42377423-42457058 (+)
C57BL/6NJ	ENSMUSG00215045993	protein coding gene	ChrX:39040064-39119690 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033099	protein coding gene	ChrX:52335869-52406982 (+)
CAST/EiJ	ENSTCUG00005019377	protein coding gene	ChrX:40681074-40765965 (+)
CBA/J	ENSMUSG00210036874	protein coding gene	ChrX:39209712-39289381 (+)
DBA/2J	ENSMUSG00185034251	protein coding gene	ChrX:51528112-51607794 (+)
FVB/NJ	ENSMUSG00205027104	protein coding gene	ChrX:38856891-38930238 (+)
JF1/MsJ	ENSUMUG00000023795	protein coding gene	ChrX:72431186-72508958 (+)
LP/J	ENSMUSG00230028708	protein coding gene	ChrX:58058223-58137895 (+)
NOD/ShiLtJ	ENSMUSG00190033391	protein coding gene	ChrX:38540246-38619917 (+)
NZO/HlLtJ	ENSMUSG00225032286	protein coding gene	ChrX:63299402-63379023 (+)
PWK/PhJ	ENSLUMG00010039370	protein coding gene	ChrX:38381338-38460240 (+)
SPRET/EiJ	ENSMSPG00010004547	protein coding gene	ChrX:40939533-41030885 (+)
WSB/EiJ	ENSIUOG00005046784	protein coding gene	ChrX:39506579-39586245 (+)

Human Ortholog

TM9SF5P, transmembrane 9 superfamily member 5, pseudogene

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TM9SF5P, transmembrane 9 superfamily member 5, pseudogene
Links

HGNC:55623

NCBI Gene ID: 100420958
Chr Location

chrX:136961917-137002495 (+) GRCh38

MGI Vertebrate Homology

Tm9sf5 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TM9SF5P
Gene Tree

Tm9sf5

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

CvDC
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show reduced female fertility, decreased numbers of primordial and growing ovarian follicles, and impaired oocyte quality associated with oxidative stress, decreased mitochondrial membrane potential, decreased oocyte maturation, and increased aneuploidy.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tm9sf5

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS53076.1

Ensembl

ENSMUSG00000079584 (Evidence)
NCBI Gene

245423

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079584	Ensembl Gene Model \| MGI Sequence Detail	79614	C57BL/6J	± kb
transcript	ENSMUST00000114725	Ensembl \| MGI Sequence Detail	2156	Not Applicable
polypeptide	ENSMUSP00000110373	Ensembl \| MGI Sequence Detail	671	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR004240 Nonaspanin (TM9SF)

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All nucleic 1

cDNA 1

Microarray probesets 2

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MGI:6466987

Summaries

All 18

Gene Ontology 4

Phenotypes 2
Earliest

J:356355 Gallardo TD, et al., Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Genetics. 2007 Sep;177(1):179-94
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tm9sf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161053	ChrX:56454507-56454520 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24