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Ak9 Gene Detail
Summary
  • Symbol
    Ak9
  • Name
    adenylate kinase 9
  • Synonyms
    Akd1, Akd2, Gm7127, LOC215946
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685080
    NCBI Gene: 633979
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:41179433-41309565 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685080
 protein coding gene Chr10:41179433-41310530 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017171
 protein coding gene Chr10:39952131-40083890 (+)
A/J MGP_AJ_G0017148
 protein coding gene Chr10:38838161-38968340 (+)
AKR/J MGP_AKRJ_G0017108
 protein coding gene Chr10:39411164-39549668 (+)
BALB/cJ MGP_BALBcJ_G0017110
 protein coding gene Chr10:38905428-39036135 (+)
C3H/HeJ MGP_C3HHeJ_G0016931
 protein coding gene Chr10:39719701-39867658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017569
 protein coding gene Chr10:41165029-41299308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015265
 protein coding gene Chr10:36779911-36907064 (+)
CAST/EiJ MGP_CASTEiJ_G0016510
 protein coding gene Chr10:39927286-40057252 (+)
CBA/J MGP_CBAJ_G0016905
 protein coding gene Chr10:43035485-43185470 (+)
DBA/2J MGP_DBA2J_G0017010
 protein coding gene Chr10:38336998-38464942 (+)
FVB/NJ MGP_FVBNJ_G0017005
 protein coding gene Chr10:37828348-37960738 (+)
LP/J MGP_LPJ_G0017087
 protein coding gene Chr10:39938955-40072570 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017035
 protein coding gene Chr10:43857961-44015416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017606
 protein coding gene Chr10:39383371-39525612 (+)
PWK/PhJ MGP_PWKPhJ_G0016290
 protein coding gene Chr10:38221743-38346945 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016074
 protein coding gene Chr10:39201539-39349599 (+)
WSB/EiJ MGP_WSBEiJ_G0016573
 protein coding gene Chr10:39723419-39859672 (+)



Homology
more
  • Human Ortholog
    AK9, adenylate kinase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AK9, adenylate kinase 9
  • Synonyms
    AK 9, AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1, SPGF89
  • Links
    NCBI Gene ID: 221264
    neXtProt AC: NX_Q5TCS8
    UniProt: Q5TCS8

  • Chr Location
    6q21; chr6:109492855-109691217 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ak9 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility associated with asthenozoospermia. Homozygosity for a certain KO allele affects cilia motility and leads to male infertility and hydrocephalus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    7
  • cDNA Data
    7
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      31
    • RefSeq
      5
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 633979 NCBI Gene Model | MGI Sequence Detail 130133 C57BL/6J ±  kb
    transcript NM_001370813 RefSeq | MGI Sequence Detail 6003 C57BL/6  
    polypeptide NP_001357742 RefSeq | MGI Sequence Detail 1879 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR000850 Adenylate kinase/UMP-CMP kinase
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7
    Other
    Accession IDs
    less
    MGI:3779674
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:344356 Yang HW, et al., A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2300681120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory