Dnah7b MGI Mouse Gene Detail - MGI:2684953 - dynein, axonemal, heavy chain 7B

Symbol

Dnah7b
Name

dynein, axonemal, heavy chain 7B
Synonyms

Dnahc7b, LOC227058

Feature Type

protein coding gene
IDs

MGI:2684953
NCBI Gene: 227058
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:46105475-46412710 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 23.96 cM
Mapping Data

1 experiment

SNPs within 2kb

7476 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684953	protein coding gene	Chr1:46105232-46412711 (+)
129S1/SvImJ	ENSMUSG00200001435	protein coding gene	Chr1:43758793-44351674 (+)
A/J	ENSMUSG00195001836	protein coding gene	Chr1:43494077-43814076 (+)
AKR/J	ENSMUSG00220003426	protein coding gene	Chr1:43349426-43630699 (+)
BALB/cJ	ENSMUSG00180002942	protein coding gene	Chr1:43452790-44195763 (+)
C3H/HeJ	ENSMUSG00175000055	protein coding gene	Chr1:43525408-43844037 (+)
C57BL/6NJ	ENSMUSG00215002953	protein coding gene	Chr1:43429212-44171424 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005000633	protein coding gene	Chr1:43407549-43705737 (+)
CBA/J	ENSMUSG00210027167	protein coding gene	Chr1:43221974-43540500 (+)
DBA/2J	ENSMUSG00185028557	protein coding gene	Chr1:44348738-44667260 (+)
FVB/NJ	no annotation
JF1/MsJ	ENSUMUG00000001062	protein coding gene	Chr1:43367377-43673035 (+)
LP/J	ENSMUSG00230000919	protein coding gene	Chr1:44329077-44633233 (+)
NOD/ShiLtJ	ENSMUSG00190002337	protein coding gene	Chr1:43371615-43682313 (+)
NZO/HlLtJ	ENSMUSG00225000214	protein coding gene	Chr1:47564216-47868423 (+)
PWK/PhJ	ENSLUMG00010002589	protein coding gene	Chr1:42936618-43660801 (+)
SPRET/EiJ	ENSMSPG00010012160	protein coding gene	Chr1:44652597-45335327 (+)
WSB/EiJ	no annotation

Human Ortholog

DNAH7, dynein axonemal heavy chain 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAH7, dynein axonemal heavy chain 7
Synonyms

CILD50
Links

HGNC:18661

NCBI Gene ID: 56171

UniProt: Q8WXX0
Chr Location

2q32.3; chr2:195737703-196068837 (-) GRCh38

MGI Vertebrate Homology

Dnah7b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAH7
Gene Tree

Dnah7b

Diseases

1 with human DNAH7 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia IDs primary ciliary dyskinesia DOID:9562 DOID:2925 MESH:D002925 NCI:C84638 OMIM:PS244400 ORDO:244 UMLS_CUI:C0008780

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Dnah7b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

203 strains or lines available

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

601
Tissues

2
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

95
RefSeq

54
UniProt

5
CCDS

CCDS48253.1, CCDS87825.1

Ensembl

ENSMUSG00000041144 (Evidence)
NCBI Gene

227058

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041144	Ensembl Gene Model \| MGI Sequence Detail	307236	C57BL/6J	± kb
transcript	ENSMUST00000069293	Ensembl \| MGI Sequence Detail	12318	Not Applicable
polypeptide	ENSMUSP00000068738	Ensembl \| MGI Sequence Detail	4068	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR026983 Dynein heavy chain

IPR041589 Dynein heavy chain 3, AAA+ lid domain

IPR043157 Dynein heavy chain, AAA1 domain, small subdomain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR041658 Dynein heavy chain, AAA lid domain

IPR042219 Dynein heavy chain, AAA lid domain superfamily

IPR024317 Dynein heavy chain, AAA module D4

IPR035706 Dynein heavy chain, ATP-binding dynein motor region

IPR024743 Dynein heavy chain, coiled coil stalk

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR004273 Dynein heavy chain, D6 P-loop domain

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

A0A571BD48 3 sites

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All nucleic 3

cDNA 3

Antibodies 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnah7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6609	Chr1:46105980-46106004 (+)	517 bp
Tssr6610	Chr1:46106006-46106055 (+)	556 bp
Tssr6611	Chr1:46128034-46128041 (+)	22,563 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29