Unc79 MGI Mouse Gene Detail - MGI:2684729

Symbol

Unc79
Name

unc-79 homolog
Synonyms

9030205A07Rik, Mlca3

Feature Type

protein coding gene
IDs

MGI:2684729
NCBI Gene: 217843
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:102915118-103150324 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.68 cM
Mapping Data

3 experiments

SNPs within 2kb

6807 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684729	protein coding gene	Chr12:102913642-103150487 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020043	protein coding gene	Chr12:104605911-104860316 (+)
A/J	MGP_AJ_G0019999	protein coding gene	Chr12:100586008-100823441 (+)
AKR/J	MGP_AKRJ_G0019975	protein coding gene	Chr12:103425114-103666014 (+)
BALB/cJ	MGP_BALBcJ_G0019985	protein coding gene	Chr12:100941085-101179072 (+)
C3H/HeJ	MGP_C3HHeJ_G0019787	protein coding gene	Chr12:103906652-104157863 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020434	protein coding gene	Chr12:107859787-108113526 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018047	protein coding gene	Chr12:97627273-97863370 (+)
CAST/EiJ	MGP_CASTEiJ_G0019333	protein coding gene	Chr12:98755679-99012114 (+)
CBA/J	MGP_CBAJ_G0019759	protein coding gene	Chr12:111861769-112133733 (+)
DBA/2J	MGP_DBA2J_G0019870	protein coding gene	Chr12:100150676-100344155 (+)
FVB/NJ	MGP_FVBNJ_G0019859	protein coding gene	Chr12:98884551-99079984 (+)
LP/J	MGP_LPJ_G0019946	protein coding gene	Chr12:104498792-104703444 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019899	protein coding gene	Chr12:115324982-115588637 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020463	protein coding gene	Chr12:102959330-103204196 (+)
PWK/PhJ	MGP_PWKPhJ_G0019096	protein coding gene	Chr12:94664288-94905697 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018892	protein coding gene	Chr12:97200077-97403755 (+)
WSB/EiJ	MGP_WSBEiJ_G0019387	protein coding gene	Chr12:103891070-104093464 (+)

Human Ortholog

UNC79, unc-79 homolog, NALCN channel complex subunit

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC79, unc-79 homolog, NALCN channel complex subunit
Synonyms

KIAA1409
Links

HGNC:19966

NCBI Gene ID: 57578

neXtProt AC: NX_Q9P2D8

UniProt: Q9P2D8
Chr Location

14q32.12; chr14:93333182-93707876 (+) GRCh38

MGI Vertebrate Homology

Unc79 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UNC79
Gene Tree

Unc79

less

Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (ENU)

1
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Unc79
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

126 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation results in lethality within the first week after birth, mostly at P0 or P1. Pups fail to nurse and have no milk in stomachs resulting in weakness, inactivity and no weight gain.

less

All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

99
RefSeq

48
UniProt

8
CCDS

CCDS49149.2

Ensembl

ENSMUSG00000021198 (Evidence)
NCBI Gene

217843

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021198	Ensembl Gene Model \| MGI Sequence Detail	235207	C57BL/6J	± kb
transcript	ENSMUST00000179002	Ensembl \| MGI Sequence Detail	7965	Not Applicable
polypeptide	ENSMUSP00000136332	Ensembl \| MGI Sequence Detail	2654	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000030850 protein unc-79 homolog

(term hierarchy)
PDB

7W7G
InterPro Domains

IPR016024 Armadillo-type fold

IPR024855 UNC79

less

All nucleic 18

cDNA 18

Microarray probesets 3

less

MGI:3701678

Summaries

All 28

Gene Ontology 6

Phenotypes 8
Earliest

J:111319 Nakayama M, et al., A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006 Aug;20(10):1718-20
Latest

J:291847 Wie J, et al., Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nat Commun. 2020 Jul 3;11(1):3351

TSS for Unc79:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114787	Chr12:102915102-102915133 (+)	0 bp
Tssr114788	Chr12:102915461-102915492 (+)	359 bp
Tssr114789	Chr12:102915493-102915538 (+)	398 bp
Tssr114790	Chr12:102915709-102915746 (+)	610 bp
Tssr114791	Chr12:102920346-102920350 (+)	5,230 bp
Tssr114792	Chr12:102959768-102959781 (+)	44,657 bp
Tssr114793	Chr12:103028637-103028638 (+)	113,520 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/03/2024 MGI 6.24