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Tusc1 Gene Detail
Summary
  • Symbol
    Tusc1
  • Name
    tumor suppressor candidate 1
  • Synonyms
    2200001D17Rik, TSG-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684283
    NCBI Gene: 69136
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:93222385-93223748 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 43.25 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684283
protein coding gene Chr4:93222375-93223748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028447
protein coding gene Chr4:93337412-93338786 (-)
A/J MGP_AJ_G0028410
protein coding gene Chr4:90113244-90114620 (-)
AKR/J MGP_AKRJ_G0028357
protein coding gene Chr4:92244970-92246347 (-)
BALB/cJ MGP_BALBcJ_G0028428
protein coding gene Chr4:90359366-90360742 (-)
C3H/HeJ MGP_C3HHeJ_G0028141
protein coding gene Chr4:93089577-93090953 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028867
protein coding gene Chr4:96930260-96937574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026161
protein coding gene Chr4:85668123-85669488 (-)
CAST/EiJ MGP_CASTEiJ_G0027581
protein coding gene Chr4:90944973-90946348 (-)
CBA/J MGP_CBAJ_G0028110
protein coding gene Chr4:99894441-99895817 (-)
DBA/2J MGP_DBA2J_G0028260
protein coding gene Chr4:89869852-89871244 (-)
FVB/NJ MGP_FVBNJ_G0028227
protein coding gene Chr4:88748204-88749576 (-)
LP/J MGP_LPJ_G0028360
protein coding gene Chr4:93657927-93659301 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028256
protein coding gene Chr4:105567737-105569113 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028905
protein coding gene Chr4:92506724-92508097 (-)
PWK/PhJ MGP_PWKPhJ_G0027306
protein coding gene Chr4:88056685-88058059 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027126
protein coding gene Chr4:89927273-89928653 (-)
WSB/EiJ MGP_WSBEiJ_G0027659
protein coding gene Chr4:92665315-92666693 (-)



Homology
more
  • Human Ortholog
    TUSC1, tumor suppressor candidate 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUSC1, tumor suppressor candidate 1
  • Synonyms
    CCDC89B, TSG9, TSG-9
  • Links
    NCBI Gene ID: 286319
    neXtProt AC: NX_Q2TAM9
    UniProt: Q2TAM9

  • Chr Location
    9p21.2; chr9:25676969-25678444 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69136 NCBI Gene Model | MGI Sequence Detail 1364 C57BL/6J ±  kb
    transcript NM_026954 RefSeq | MGI Sequence Detail 1364 Not Specified  
    polypeptide Q673H1 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 1
      cDNA 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916386
    References
    more
    • Summaries
      All 28
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory