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Tusc1 Gene Detail
Summary
  • Symbol
    Tusc1
  • Name
    tumor suppressor candidate 1
  • Synonyms
    2200001D17Rik, TSG-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684283
    NCBI Gene: 69136
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:93222385-93223748 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 43.25 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684283
 protein coding gene Chr4:93222375-93223748 (-)
129S1/SvImJ ENSMUSG00200008992
 protein coding gene Chr4:88175049-88176423 (-)
A/J ENSMUSG00195008857
 protein coding gene Chr4:88773863-88775239 (-)
AKR/J ENSMUSG00220019452
 protein coding gene Chr4:88178298-88179675 (-)
BALB/cJ ENSMUSG00180005633
 protein coding gene Chr4:87721367-87722743 (-)
C3H/HeJ ENSMUSG00175007800
 protein coding gene Chr4:88660552-88661928 (-)
C57BL/6NJ ENSMUSG00215011242
 protein coding gene Chr4:88578186-88579558 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026161
 protein coding gene Chr4:85668123-85669488 (-)
CAST/EiJ ENSTCUG00005018705
 protein coding gene Chr4:88041986-88043361 (-)
CBA/J ENSMUSG00210016033
 protein coding gene Chr4:88237229-88238605 (-)
DBA/2J ENSMUSG00185002579
 protein coding gene Chr4:88980286-88981659 (-)
FVB/NJ ENSMUSG00205011535
 protein coding gene Chr4:87147880-87149252 (-)
JF1/MsJ ENSUMUG00000001366
 protein coding gene Chr4:89144576-89145950 (-)
LP/J ENSMUSG00230017563
 protein coding gene Chr4:92285941-92287315 (-)
NOD/ShiLtJ ENSMUSG00190015928
 protein coding gene Chr4:87675373-87676749 (-)
NZO/HlLtJ ENSMUSG00225002553
 protein coding gene Chr4:97442526-97443898 (-)
PWK/PhJ ENSLUMG00010002989
 protein coding gene Chr4:86904960-86906334 (-)
SPRET/EiJ ENSMSPG00010014572
 protein coding gene Chr4:88808280-88809668 (-)
WSB/EiJ ENSIUOG00005012514
 protein coding gene Chr4:87987449-87988828 (-)



Homology
more
  • Human Ortholog
    TUSC1, tumor suppressor candidate 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUSC1, tumor suppressor candidate 1
  • Synonyms
    CCDC89B, TSG-9, TSG9
  • Links
    NCBI Gene ID: 286319
    UniProt: Q2TAM9

  • Chr Location
    9p21.2; chr9:25676969-25678444 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69136 NCBI Gene Model | MGI Sequence Detail 1364 C57BL/6J ±  kb
    transcript NM_026954 RefSeq | MGI Sequence Detail 1364 Not Specified  
    polypeptide Q673H1 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 1
      cDNA 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916386
    References
    more
    • Summaries
      All 32
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory