Prdm10 MGI Mouse Gene Detail - MGI:2682952

Symbol

Prdm10
Name

PR domain containing 10
Synonyms

LOC382066, MGC:73898, tristanin

Feature Type

protein coding gene
IDs

MGI:2682952
NCBI Gene: 382066
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:31191834-31293019 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 16.77 cM
Mapping Data

1 experiment

SNPs within 2kb

2610 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2682952	protein coding gene	Chr9:31187406-31293027 (+)
129S1/SvImJ	ENSMUSG00200007466	protein coding gene	Chr9:28190536-28291727 (+)
A/J	ENSMUSG00195005507	protein coding gene	Chr9:28002512-28103725 (+)
AKR/J	ENSMUSG00220010409	protein coding gene	Chr9:28032244-28133445 (+)
BALB/cJ	ENSMUSG00180006392	protein coding gene	Chr9:28130982-28232193 (+)
C3H/HeJ	ENSMUSG00175018798	protein coding gene	Chr9:28111503-28212696 (+)
C57BL/6NJ	ENSMUSG00215007856	protein coding gene	Chr9:28087382-28188572 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031938	protein coding gene	Chr9:27073217-27175847 (+)
CAST/EiJ	ENSTCUG00005018757	protein coding gene	Chr9:28091961-28191624 (+)
CBA/J	ENSMUSG00210022075	protein coding gene	Chr9:28141838-28243021 (+)
DBA/2J	ENSMUSG00185002156	protein coding gene	Chr9:28183806-28285177 (+)
FVB/NJ	ENSMUSG00205003748	protein coding gene	Chr9:28485962-28587154 (+)
JF1/MsJ	ENSUMUG00000009450	protein coding gene	Chr9:28357108-28467126 (+)
LP/J	ENSMUSG00230004197	protein coding gene	Chr9:28620846-28722046 (+)
NOD/ShiLtJ	ENSMUSG00190005695	protein coding gene	Chr9:28223262-28324441 (+)
NZO/HlLtJ	ENSMUSG00225014684	protein coding gene	Chr9:28599480-28700874 (+)
PWK/PhJ	ENSLUMG00010009104	protein coding gene	Chr9:28223370-28324423 (+)
SPRET/EiJ	ENSMSPG00010002083	protein coding gene	Chr9:28587012-28687026 (+)
WSB/EiJ	ENSIUOG00005015406	protein coding gene	Chr9:27664331-27765496 (+)

Human Ortholog

PRDM10, PR/SET domain 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRDM10, PR/SET domain 10
Synonyms

BHD2, PFM7, TRIS
Links

HGNC:13995

NCBI Gene ID: 56980

UniProt: Q9NQV6
Chr Location

11q24.3; chr11:129899706-130002853 (-) GRCh38

MGI Vertebrate Homology

Prdm10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRDM10
Gene Tree

Prdm10

Diseases

1 with human PRDM10 associations

				Human Disease	Mouse Models
				Birt-Hogg-Dube syndrome IDs Birt-Hogg-Dube syndrome DOID:0050676 MESH:D058249 OMIM:135150

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Endonuclease-mediated

1
Gene trapped

40
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout is embryonic lethal.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

626
Tissues

27
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PRDM10

Xenbase prdm10

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All Sequences

67
RefSeq

28
UniProt

4
CCDS

CCDS40570.1, CCDS90529.1

Ensembl

ENSMUSG00000042496 (Evidence)
NCBI Gene

382066

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042496	Ensembl Gene Model \| MGI Sequence Detail	101186	C57BL/6J	± kb
transcript	ENSMUST00000215847	Ensembl \| MGI Sequence Detail	3519	Not Applicable
polypeptide	ENSMUSP00000149699	Ensembl \| MGI Sequence Detail	1172	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013180 PR domain zinc finger protein 10

(term hierarchy)
InterPro Domains

IPR044403 PRDM10, PR/SET domain

IPR001214 SET domain

IPR046341 SET domain superfamily

IPR050688 Zinc finger and ubiquitin peptidase domain-containing protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q3UTQ7 2 sites

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All nucleic 9

cDNA 7

Primer pair 2

Antibodies 1

Microarray probesets 3

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MGI:2685958

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:361963 Seah MKY, et al., Maternal PRDM10 activates essential genes for oocyte-to-embryo transition. Nat Commun. 2025 Feb 24;16(1):1939

TSS for Prdm10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84220	Chr9:31191821-31191862 (+)	8 bp
Tssr84223	Chr9:31265612-31265636 (+)	73,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24