Tmprss13 MGI Mouse Gene Detail - MGI:2682935 - transmembrane protease, serine 13

Symbol

Tmprss13
Name

transmembrane protease, serine 13

Feature Type

protein coding gene
IDs

MGI:2682935
NCBI Gene: 214531
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:45230398-45258879 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

2 experiments

SNPs within 2kb

1084 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2682935	protein coding gene	Chr9:45230286-45258879 (+)
129S1/SvImJ	ENSMUSG00200018004	protein coding gene	Chr9:42308431-42337269 (+)
A/J	ENSMUSG00195018578	protein coding gene	Chr9:42075873-42104409 (+)
AKR/J	ENSMUSG00220034892	protein coding gene	Chr9:42153496-42182165 (+)
BALB/cJ	ENSMUSG00180028186	protein coding gene	Chr9:42187555-42216089 (+)
C3H/HeJ	ENSMUSG00175012355	protein coding gene	Chr9:42199466-42228005 (+)
C57BL/6NJ	ENSMUSG00215017258	protein coding gene	Chr9:42150977-42179468 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032143	protein coding gene	Chr9:42197756-42226591 (+)
CAST/EiJ	ENSTCUG00005013904	protein coding gene	Chr9:42136486-42165257 (+)
CBA/J	ENSMUSG00210016155	protein coding gene	Chr9:42236094-42264641 (+)
DBA/2J	ENSMUSG00185011331	protein coding gene	Chr9:42314153-42342679 (+)
FVB/NJ	ENSMUSG00205040015	protein coding gene	Chr9:42553412-42581933 (+)
JF1/MsJ	ENSUMUG00000017982	protein coding gene	Chr9:42348346-42377208 (+)
LP/J	ENSMUSG00230036410	protein coding gene	Chr9:42598813-42627631 (+)
NOD/ShiLtJ	ENSMUSG00190017715	protein coding gene	Chr9:42392866-42421394 (+)
NZO/HlLtJ	ENSMUSG00225044065	protein coding gene	Chr9:42566936-42595571 (+)
PWK/PhJ	ENSLUMG00010020835	protein coding gene	Chr9:42306592-42335560 (+)
SPRET/EiJ	ENSMSPG00010010688	protein coding gene	Chr9:43069712-43097196 (+)
WSB/EiJ	ENSIUOG00005017307	protein coding gene	Chr9:41796796-41825540 (+)

Human Ortholog

TMPRSS13, transmembrane serine protease 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMPRSS13, transmembrane serine protease 13
Synonyms

MSP, MSPL, MSPS, TMPRSS11
Links

HGNC:29808

NCBI Gene ID: 84000

UniProt: Q9BYE2
Chr Location

11q23.3; chr11:117900641-117929459 (-) GRCh38

MGI Vertebrate Homology

Tmprss13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMPRSS13
Protein SuperFamily

TMPRSS13
Gene Tree

Tmprss13

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and outwardly healthy but exhibit abnormal stratum corneum formation leading to impaired skin barrier function, as measured by the transepidermal fluid loss rate in newborn pups.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

677
Tissues

56
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmprss13

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS23132.1

Ensembl

ENSMUSG00000037129 (Evidence)
NCBI Gene

214531

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037129	Ensembl Gene Model \| MGI Sequence Detail	28482	C57BL/6J	± kb
transcript	ENSMUST00000034597	Ensembl \| MGI Sequence Detail	3245	Not Applicable
polypeptide	ENSMUSP00000034597	Ensembl \| MGI Sequence Detail	548	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016455 transmembrane protease serine 13

(term hierarchy)
EC

3.4.21.-, 3.4.21.1
InterPro Domains

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

IPR001314 Peptidase S1A, chymotrypsin family

IPR017327 Peptidase S1A, TMPRSS13

IPR009003 Peptidase S1, PA clan

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR001254 Serine proteases, trypsin domain

IPR033116 Serine proteases, trypsin family, serine active site

IPR001190 SRCR domain

IPR036772 SRCR-like domain superfamily
GlyGen

Q5U405 4 sites

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All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 5
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303

TSS for Tmprss13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84762	Chr9:45230280-45230317 (+)	-99 bp
Tssr84763	Chr9:45230319-45230360 (+)	-58 bp
Tssr84764	Chr9:45230370-45230384 (+)	-21 bp
Tssr84765	Chr9:45239792-45239806 (+)	9,401 bp
Tssr84766	Chr9:45258102-45258105 (+)	27,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24