Zfp335 MGI Mouse Gene Detail - MGI:2682313

Symbol

Zfp335
Name

zinc finger protein 335
Synonyms

1810045J01Rik, MGC:86001

Feature Type

protein coding gene
IDs

MGI:2682313
NCBI Gene: 329559
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:164733802-164753677 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.27 cM
Mapping Data

2 experiments

SNPs within 2kb

505 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2682313	protein coding gene	Chr2:164733802-164756034 (-)
129S1/SvImJ	ENSMUSG00200016521	protein coding gene	Chr2:161622752-161642647 (-)
A/J	ENSMUSG00195024063	protein coding gene	Chr2:161954454-161974747 (-)
AKR/J	ENSMUSG00220012965	protein coding gene	Chr2:161283936-161304244 (-)
BALB/cJ	ENSMUSG00180048578	protein coding gene	Chr2:161408165-161428458 (-)
C3H/HeJ	ENSMUSG00175050536	protein coding gene	Chr2:162158776-162179067 (-)
C57BL/6NJ	ENSMUSG00215028790	protein coding gene	Chr2:161606710-161626586 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024676	protein coding gene	Chr2:156837862-156859165 (-)
CAST/EiJ	ENSTCUG00005045078	protein coding gene	Chr2:160525495-160545568 (-)
CBA/J	ENSMUSG00210016360	protein coding gene	Chr2:162088812-162109098 (-)
DBA/2J	ENSMUSG00185042205	protein coding gene	Chr2:161825916-161846199 (-)
FVB/NJ	ENSMUSG00205028620	protein coding gene	Chr2:160846820-160867102 (-)
JF1/MsJ	ENSUMUG00000022742	protein coding gene	Chr2:161465911-161486338 (-)
LP/J	ENSMUSG00230039708	protein coding gene	Chr2:163383852-163403739 (-)
NOD/ShiLtJ	ENSMUSG00190029569	protein coding gene	Chr2:161493670-161513960 (-)
NZO/HlLtJ	ENSMUSG00225050885	protein coding gene	Chr2:171388252-171408533 (-)
PWK/PhJ	ENSLUMG00010046451	protein coding gene	Chr2:161368272-161388190 (-)
SPRET/EiJ	ENSMSPG00010027641	protein coding gene	Chr2:164128465-164148406 (-)
WSB/EiJ	ENSIUOG00005044512	protein coding gene	Chr2:161214737-161234991 (-)

Human Ortholog

ZNF335, zinc finger protein 335

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF335, zinc finger protein 335
Synonyms

MCPH10, NIF-1, NIF1, NIF2
Links

HGNC:15807

NCBI Gene ID: 63925

UniProt: Q9H4Z2
Chr Location

20q13.12; chr20:45948653-45972206 (-) GRCh38

MGI Vertebrate Homology

Zfp335 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF335
Gene Tree

Zfp335

Diseases

1 with human ZNF335 associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly 10 IDs primary autosomal recessive microcephaly 10 DOID:0070294 OMIM:615095

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 5 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

5
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality before implantation. Mice homozygous for a conditional allele activated in the brain exhibit loss of cortical neurons and decreased brain size.

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All GO Annotations

47
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

628
Tissues

15
cDNA Data

43
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

10
UniProt

4
CCDS

CCDS38331.1

Ensembl

ENSMUSG00000039834 (Evidence)
NCBI Gene

329559

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039834	Ensembl Gene Model \| MGI Sequence Detail	19876	C57BL/6J	± kb
transcript	ENSMUST00000041361	Ensembl \| MGI Sequence Detail	4587	Not Applicable
polypeptide	ENSMUSP00000038298	Ensembl \| MGI Sequence Detail	1337	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017836 zinc finger protein 335

(term hierarchy)
InterPro Domains

IPR050688 Zinc finger and ubiquitin peptidase domain-containing protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

A2A5K6 3 sites, 1 O-linked glycan (1 site)

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All nucleic 45

cDNA 45

Antibodies 2

Microarray probesets 3

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MGI:1917051

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:334079 Ratiu JJ, et al., Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-beta selection thymocytes. Nat Commun. 2022 Oct 6;13(1):5901

TSS for Zfp335:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27597	Chr2:164753506-164753528 (-)	160 bp
Tssr27596	Chr2:164753480-164753503 (-)	185 bp
Tssr27595	Chr2:164753178-164753219 (-)	478 bp
Tssr27594	Chr2:164753138-164753159 (-)	528 bp
Tssr27593	Chr2:164753095-164753130 (-)	564 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24