Prss34 MGI Mouse Gene Detail - MGI:2681414

Symbol

Prss34
Name

serine protease 34
Synonyms

mast cell protease 11, mMcp-11

Feature Type

protein coding gene
IDs

MGI:2681414
NCBI Gene: 328780
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:25517368-25519142 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.53 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

154 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681414	protein coding gene	Chr17:25517368-25519142 (+)
129S1/SvImJ	ENSMUSG00200052791	protein coding gene	Chr17:20961576-20963347 (+)
A/J	ENSMUSG00195054302	protein coding gene	Chr17:21979303-21981074 (+)
AKR/J	ENSMUSG00220053262	protein coding gene	Chr17:21026025-21027796 (+)
BALB/cJ	ENSMUSG00180042168	protein coding gene	Chr17:21259569-21261340 (+)
C3H/HeJ	ENSMUSG00175051160	protein coding gene	Chr17:21018220-21019991 (+)
C57BL/6NJ	ENSMUSG00215054198	protein coding gene	Chr17:21025680-21027451 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021231	protein coding gene	Chr17:21131079-21132861 (+)
CAST/EiJ	ENSTCUG00005041860	protein coding gene	Chr17:21601195-21602966 (+)
CBA/J	ENSMUSG00210048784	protein coding gene	Chr17:20857026-20858797 (+)
DBA/2J	ENSMUSG00185038300	protein coding gene	Chr17:23067626-23069397 (+)
FVB/NJ	ENSMUSG00205047900	protein coding gene	Chr17:21322593-21324364 (+)
JF1/MsJ	ENSUMUG00000046797	protein coding gene	Chr17:22517193-22518964 (+)
LP/J	ENSMUSG00230054462	protein coding gene	Chr17:24466173-24467944 (+)
NOD/ShiLtJ	ENSMUSG00190033522	protein coding gene	Chr17:20956368-20958139 (+)
NZO/HlLtJ	ENSMUSG00225054272	protein coding gene	Chr17:26386738-26388509 (+)
PWK/PhJ	ENSLUMG00010053246	protein coding gene	Chr17:20434332-20436096 (+)
SPRET/EiJ	ENSMSPG00010040527	protein coding gene	Chr17:21761279-21763048 (+)
WSB/EiJ	ENSIUOG00005051186	protein coding gene	Chr17:21700416-21702187 (+)

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MGI Vertebrate Homology

Prss34 stringent orthology
1 mouse;1 rat
Gene Tree

Prss34

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Prss34
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show ameliorated IgE-mediated chronic allergic inflammation in the skin, with reduced microvascular permeability and leukocyte infiltration in the skin lesion.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

618
Tissues

21
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

3
CCDS

CCDS28514.1

Ensembl

ENSMUSG00000056399 (Evidence)
NCBI Gene

328780

			Length	Strain/Species	Flank
genomic	328780	NCBI Gene Model \| MGI Sequence Detail	1775	C57BL/6J	± kb
transcript	NM_178372	RefSeq \| MGI Sequence Detail	1216	BALB/c
polypeptide	NP_848459	RefSeq \| MGI Sequence Detail	318	BALB/c

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UniProt

3 Sequences
EC

3.4.21.1
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR001254 Serine proteases, trypsin domain

IPR051487 Serine/Threonine Proteases with Immune and Developmental Roles
GlyGen

Q80UR4 1 site, 1 N-linked glycan (1 site)

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All nucleic 5

cDNA 4

Primer pair 1

Antibodies 1

Microarray probesets 1

Summaries

All 25

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 6
Earliest

J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
Latest

J:238924 Iki M, et al., Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016 Dec 22;128(25):2909-2918

TSS for Prss34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143150	Chr17:25517363-25517377 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24