Skic3 MGI Mouse Gene Detail - MGI:2679923 - SKI3 subunit of superkiller complex

Symbol

Skic3
Name

SKI3 subunit of superkiller complex
Synonyms

mKIAA0372, Ttc37

Feature Type

protein coding gene
IDs

MGI:2679923
NCBI Gene: 218343
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:76246853-76338435 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.95 cM
Mapping Data

2 experiments

SNPs within 2kb

2560 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679923	protein coding gene	Chr13:76246837-76338437 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020778	protein coding gene	Chr13:76642327-76736114 (+)
A/J	MGP_AJ_G0020734	protein coding gene	Chr13:74033756-74125743 (+)
AKR/J	MGP_AKRJ_G0020707	protein coding gene	Chr13:76277421-76366274 (+)
BALB/cJ	MGP_BALBcJ_G0020730	protein coding gene	Chr13:74518441-74606624 (+)
C3H/HeJ	MGP_C3HHeJ_G0020524	protein coding gene	Chr13:75985393-76080604 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021167	protein coding gene	Chr13:79217727-79312042 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018735	protein coding gene	Chr13:70840967-70930822 (+)
CAST/EiJ	MGP_CASTEiJ_G0020042	protein coding gene	Chr13:75063561-75155724 (+)
CBA/J	MGP_CBAJ_G0020483	protein coding gene	Chr13:82225148-82324480 (+)
DBA/2J	MGP_DBA2J_G0020608	protein coding gene	Chr13:73739538-73830623 (+)
FVB/NJ	MGP_FVBNJ_G0020588	protein coding gene	Chr13:72799532-72885539 (+)
LP/J	MGP_LPJ_G0020681	protein coding gene	Chr13:76918443-77002094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020617	protein coding gene	Chr13:80622148-80724262 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021207	protein coding gene	Chr13:75603600-75697116 (+)
PWK/PhJ	MGP_PWKPhJ_G0019795	protein coding gene	Chr13:72653048-72743062 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019618	protein coding gene	Chr13:71969757-72063334 (+)
WSB/EiJ	MGP_WSBEiJ_G0020099	protein coding gene	Chr13:76099941-76206322 (+)

Human Ortholog

SKIC3, SKI3 subunit of superkiller complex

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SKIC3, SKI3 subunit of superkiller complex
Synonyms

KIAA0372, Ski3, THES, TTC37
Links

HGNC:23639

NCBI Gene ID: 9652

neXtProt AC: NX_Q6PGP7

UniProt: Q6PGP7
Chr Location

5q15; chr5:95461755-95555050 (-) GRCh38

MGI Vertebrate Homology

Skic3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SKIC3
Gene Tree

Skic3

Diseases

1 with human SKIC3 associations

				Human Disease	Mouse Models
				trichohepatoenteric syndrome 1 IDs trichohepatoenteric syndrome 1 DOID:0111415 OMIM:222470

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

14
Genomic Mutations

1 involving Skic3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

81 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show decreased embryo size, embryonic growth retardation, a small egg cylinder, disorganized extraembryonic tissue, and complete embryonic lethality by E9.5.

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All GO Annotations

16
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

70

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase skic3

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All Sequences

79
RefSeq

26
UniProt

6
CCDS

CCDS36735.1

Ensembl

ENSMUSG00000033991 (Evidence)
NCBI Gene

218343

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033991	Ensembl Gene Model \| MGI Sequence Detail	91583	C57BL/6J	± kb
transcript	ENSMUST00000224386	Ensembl \| MGI Sequence Detail	6976	Not Applicable
polypeptide	ENSMUSP00000153521	Ensembl \| MGI Sequence Detail	1563	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031982 superkiller complex protein 3

(term hierarchy)
InterPro Domains

IPR039226 Ski3/TTC37

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

F8VPK0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 71

cDNA 71

Microarray probesets 4

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MGI:7382775

Summaries

All 39

Gene Ontology 4

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Skic3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120418	Chr13:76246882-76246893 (+)	35 bp
Tssr120419	Chr13:76246894-76246928 (+)	58 bp
Tssr120420	Chr13:76247997-76248000 (+)	1,146 bp
Tssr120421	Chr13:76263391-76263397 (+)	16,541 bp
Tssr120422	Chr13:76278312-76278321 (+)	31,464 bp
Tssr120423	Chr13:76278387-76278414 (+)	31,548 bp
Tssr120424	Chr13:76337192-76337198 (+)	90,342 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24