Tdrd6 MGI Mouse Gene Detail - MGI:2679727 - tudor domain containing 6

Symbol

Tdrd6
Name

tudor domain containing 6

Feature Type

protein coding gene
IDs

MGI:2679727
NCBI Gene: 210510
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:43926226-43941190 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.75 cM
Mapping Data

1 experiment

SNPs within 2kb

526 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679727	protein coding gene	Chr17:43926225-43942737 (-)
129S1/SvImJ	ENSMUSG00200045638	protein coding gene	Chr17:39122638-39137574 (-)
A/J	ENSMUSG00195018987	protein coding gene	Chr17:40628865-40643808 (-)
AKR/J	ENSMUSG00220037078	protein coding gene	Chr17:39587751-39602689 (-)
BALB/cJ	ENSMUSG00180018404	protein coding gene	Chr17:40372116-40387054 (-)
C3H/HeJ	ENSMUSG00175036581	protein coding gene	Chr17:39669416-39684354 (-)
C57BL/6NJ	ENSMUSG00215052480	protein coding gene	Chr17:39229678-39244639 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021632	protein coding gene	Chr17:40336765-40351694 (-)
CAST/EiJ	ENSTCUG00005023789	protein coding gene	Chr17:40433557-40448535 (-)
CBA/J	ENSMUSG00210042597	protein coding gene	Chr17:39419241-39434181 (-)
DBA/2J	ENSMUSG00185027656	protein coding gene	Chr17:42352911-42367849 (-)
FVB/NJ	ENSMUSG00205026039	protein coding gene	Chr17:39908206-39923131 (-)
JF1/MsJ	ENSUMUG00000019131	protein coding gene	Chr17:41969808-41984795 (-)
LP/J	ENSMUSG00230040412	protein coding gene	Chr17:43225655-43240588 (-)
NOD/ShiLtJ	ENSMUSG00190034540	protein coding gene	Chr17:39322698-39337639 (-)
NZO/HlLtJ	ENSMUSG00225042706	protein coding gene	Chr17:45494346-45509228 (-)
PWK/PhJ	ENSLUMG00010040378	protein coding gene	Chr17:39197882-39212839 (-)
SPRET/EiJ	ENSMSPG00010031823	protein coding gene	Chr17:39406341-39421360 (-)
WSB/EiJ	ENSIUOG00005047225	protein coding gene	Chr17:40290615-40305579 (-)

Human Ortholog

TDRD6, tudor domain containing 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD6, tudor domain containing 6
Synonyms

bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2
Links

HGNC:21339

NCBI Gene ID: 221400

UniProt: O60522
Chr Location

6p12.3; chr6:46680268-46704319 (+) GRCh38

MGI Vertebrate Homology

Tdrd6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TDRD6
Gene Tree

Tdrd6

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
5 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

3
Transposon induced

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

81 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility associated with arrested spermatogenesis.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

678
Tissues

20
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd6

ZFIN tdrd6a

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All Sequences

54
RefSeq

14
UniProt

6
CCDS

CCDS28797.1, CCDS50115.1, CCDS89099.1

Ensembl

ENSMUSG00000040140 (Evidence)
NCBI Gene

210510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040140	Ensembl Gene Model \| MGI Sequence Detail	14965	C57BL/6J	± kb
transcript	ENSMUST00000045717	Ensembl \| MGI Sequence Detail	6563	Not Applicable
polypeptide	ENSMUSP00000035338	Ensembl \| MGI Sequence Detail	2135	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031299 tudor domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR035437 SNase-like, OB-fold superfamily

IPR047444 TDRD6, first Tudor domain

IPR047445 TDRD6, second Tudor domain

IPR002999 Tudor domain

IPR050621 Tudor domain-containing
GlyGen

P61407 2 sites

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All nucleic 11

cDNA 9

Primer pair 2

Antibodies 4

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 9
Earliest

J:101737 Pan J, et al., RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39
Latest

J:369090 Bi X, et al., Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice. J Cell Mol Med. 2024 Sep;28(18):e18580

TSS for Tdrd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148149	Chr17:43941577-43941588 (-)	-393 bp
Tssr5122	Chr17:43941519-43941542 (-)	-341 bp
Tssr148148	Chr17:43941201-43941204 (-)	-13 bp
Tssr148147	Chr17:43941181-43941195 (-)	2 bp
Tssr148146	Chr17:43941171-43941180 (-)	14 bp
Tssr148145	Chr17:43939496-43939504 (-)	1,690 bp
Tssr148144	Chr17:43939462-43939470 (-)	1,724 bp
Tssr148143	Chr17:43935299-43935309 (-)	5,886 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29