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Mthfsd Gene Detail
Summary
  • Symbol
    Mthfsd
  • Name
    methenyltetrahydrofolate synthetase domain containing
  • Synonyms
    MGC:62465
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679252
    NCBI Gene: 234814
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121818367-121835131 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679252
protein coding gene Chr8:121818367-121835152 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034208
protein coding gene Chr8:124569007-124585771 (-)
A/J MGP_AJ_G0034188
protein coding gene Chr8:119389139-119405903 (-)
AKR/J MGP_AKRJ_G0034115
protein coding gene Chr8:122873219-122889983 (-)
BALB/cJ MGP_BALBcJ_G0034182
protein coding gene Chr8:119606000-119623152 (-)
C3H/HeJ MGP_C3HHeJ_G0033893
protein coding gene Chr8:123603846-123621318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034702
protein coding gene Chr8:128709456-128726220 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031644
protein coding gene Chr8:112256810-112274552 (-)
CAST/EiJ MGP_CASTEiJ_G0033220
protein coding gene Chr8:123617675-123636326 (-)
CBA/J MGP_CBAJ_G0033866
protein coding gene Chr8:133438428-133455245 (-)
DBA/2J MGP_DBA2J_G0034022
protein coding gene Chr8:118598435-118615222 (-)
FVB/NJ MGP_FVBNJ_G0033965
protein coding gene Chr8:117686898-117703824 (-)
LP/J MGP_LPJ_G0034111
protein coding gene Chr8:124695054-124711818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034012
protein coding gene Chr8:135745375-135762139 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034720
protein coding gene Chr8:123054494-123073271 (-)
PWK/PhJ MGP_PWKPhJ_G0032922
protein coding gene Chr8:118397950-118415069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032762
protein coding gene Chr8:121767460-121784039 (-)
WSB/EiJ MGP_WSBEiJ_G0033336
protein coding gene Chr8:123804725-123822875 (-)



Homology
more
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
  • Links
    NCBI Gene ID: 64779
    neXtProt AC: NX_Q2M296
    UniProt: Q2M296

  • Chr Location
    16q24.1; chr16:86530178-86555235 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031816 Ensembl Gene Model | MGI Sequence Detail 16765 C57BL/6J ±  kb
transcript ENSMUST00000116415 Ensembl | MGI Sequence Detail 1520 Not Applicable  
polypeptide ENSMUSP00000112116 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000030856 methenyltetrahydrofolate synthase domain-containing protein
  • InterPro Domains
    IPR002698 5-formyltetrahydrofolate cyclo-ligase
    IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily
    IPR037171 NagB/RpiA transferase-like
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142752
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:346362 MacNair L, et al., MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain. 2016 Jan;139(Pt 1):86-100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory