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Rnf149 Gene Detail
Summary
  • Symbol
    Rnf149
  • Name
    ring finger protein 149
  • Synonyms
    1600023E10Rik, Greul4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677438
    NCBI Gene: 67702
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:39590377-39616486 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 18.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677438
 protein coding gene Chr1:39590375-39616885 (-)
129S1/SvImJ ENSMUSG00200003688
 protein coding gene Chr1:37199071-37211278 (-)
129S1/SvImJ ENSMUSGG00200054703
 protein coding gene Chr1:37189459-37199310 (-)
A/J ENSMUSG00195038026
 protein coding gene Chr1:36874000-36886203 (-)
A/J ENSMUSGG00195055247
 protein coding gene Chr1:36864379-36874239 (-)
AKR/J ENSMUSGG00220054668
 protein coding gene Chr1:36851708-36861564 (-)
AKR/J ENSMUSG00220007977
 protein coding gene Chr1:36861325-36873535 (-)
BALB/cJ ENSMUSGG00180055261
 protein coding gene Chr1:36933373-36943227 (-)
BALB/cJ ENSMUSG00180011418
 protein coding gene Chr1:36942988-36955201 (-)
C3H/HeJ ENSMUSGG00175054919
 protein coding gene Chr1:36867454-36877314 (-)
C3H/HeJ ENSMUSG00175001300
 protein coding gene Chr1:36877075-36889276 (-)
C57BL/6NJ ENSMUSGG00215055655
 protein coding gene Chr1:36908465-36918319 (-)
C57BL/6NJ ENSMUSG00215024145
 protein coding gene Chr1:36918080-36930291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014072
 protein coding gene Chr1:34191062-34216537 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210005835
 protein coding gene Chr1:36677922-36690132 (-)
CBA/J ENSMUSGG00210054689
 protein coding gene Chr1:36668307-36678161 (-)
DBA/2J ENSMUSGG00185057717
 protein coding gene Chr1:37765221-37775074 (-)
DBA/2J ENSMUSG00185009839
 protein coding gene Chr1:37774835-37787048 (-)
FVB/NJ ENSMUSGG00205054437
 protein coding gene Chr1:36870774-36880625 (-)
FVB/NJ ENSMUSG00205026263
 protein coding gene Chr1:36880386-36892586 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230023031
 protein coding gene Chr1:37815560-37827770 (-)
LP/J ENSMUSGG00230055640
 protein coding gene Chr1:37805945-37815799 (-)
NOD/ShiLtJ ENSMUSGG00190054517
 protein coding gene Chr1:36879720-36889570 (-)
NOD/ShiLtJ ENSMUSG00190029062
 protein coding gene Chr1:36889331-36901531 (-)
NZO/HlLtJ ENSMUSGG00225055571
 protein coding gene Chr1:41067114-41076969 (-)
NZO/HlLtJ ENSMUSG00225013295
 protein coding gene Chr1:41076730-41088944 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010025643
 protein coding gene Chr1:37976827-38002653 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RNF149, ring finger protein 149
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF149, ring finger protein 149
  • Synonyms
    DNAPTP2
  • Links
    NCBI Gene ID: 284996
    UniProt: Q8NC42

  • Chr Location
    2q11.2; chr2:101271219-101308724 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Rnf149
  • Find Mice (IMSR)
    13 strains or lines available
Mice homozygous for a null mutation display hyperproliferation of several hematological cell lineages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    128
  • cDNA Data
    122
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048234 Ensembl Gene Model | MGI Sequence Detail 26110 C57BL/6J ±  kb
transcript ENSMUST00000062525 Ensembl | MGI Sequence Detail 2492 Not Applicable  
polypeptide ENSMUSP00000050388 Ensembl | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 124
    cDNA 123
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914952, MGI:2138516, MGI:2138655
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:365065 Wu M, et al., RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3. PLoS Pathog. 2025 Apr;21(4):e1013051
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory