Rcsd1 MGI Mouse Gene Detail - MGI:2676394

Symbol

Rcsd1
Name

RCSD domain containing 1
Synonyms

A430105K13Rik, MGC:32399

Feature Type

protein coding gene
IDs

MGI:2676394
NCBI Gene: 226594
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr1:165476503-165537632 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 72.99 cM
Mapping Data

3 experiments

SNPs within 2kb

2032 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676394	protein coding gene	Chr1:165474085-165537632 (-)
129S1/SvImJ	ENSMUSG00200044945	protein coding gene	Chr1:162974631-163037522 (-)
A/J	ENSMUSG00195045713	protein coding gene	Chr1:162283215-162346112 (-)
AKR/J	ENSMUSG00220013430	protein coding gene	Chr1:162071768-162134657 (-)
BALB/cJ	ENSMUSG00180036579	protein coding gene	Chr1:162528636-162591535 (-)
C3H/HeJ	ENSMUSG00175039381	protein coding gene	Chr1:162624391-162687282 (-)
C57BL/6NJ	ENSMUSG00215039364	protein coding gene	Chr1:162410292-162473176 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014808	protein coding gene	Chr1:156054201-156116508 (-)
CAST/EiJ	ENSTCUG00005019466	protein coding gene	Chr1:161055838-161118937 (-)
CBA/J	ENSMUSG00210020372	protein coding gene	Chr1:162498871-162561761 (-)
DBA/2J	ENSMUSG00185010845	protein coding gene	Chr1:166739909-166809776 (-)
FVB/NJ	ENSMUSG00205008753	protein coding gene	Chr1:161538484-161601629 (-)
JF1/MsJ	ENSUMUG00000004174	protein coding gene	Chr1:165890783-165960866 (-)
LP/J	ENSMUSG00230023362	protein coding gene	Chr1:166363710-166426603 (-)
NOD/ShiLtJ	ENSMUSG00190023671	protein coding gene	Chr1:162330694-162393432 (-)
NZO/HlLtJ	ENSMUSG00225004468	protein coding gene	Chr1:169949521-170012405 (-)
PWK/PhJ	ENSLUMG00010037818	protein coding gene	Chr1:161271464-161330817 (-)
SPRET/EiJ	ENSMSPG00010044046	protein coding gene	Chr1:164766959-164826025 (-)
WSB/EiJ	ENSIUOG00005014935	protein coding gene	Chr1:161811373-161874028 (-)

Human Ortholog

RCSD1, RCSD domain containing 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCSD1, RCSD domain containing 1
Synonyms

CAPZIP, MK2S4
Links

HGNC:28310

NCBI Gene ID: 92241

UniProt: Q6JBY9
Chr Location

1q24.2; chr1:167629660-167708706 (+) GRCh38

MGI Vertebrate Homology

Rcsd1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RCSD1
Gene Tree

Rcsd1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Targeted

3
Genomic Mutations

2 involving Rcsd1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

22
cDNA Data

28
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcsd1

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All Sequences

52
RefSeq

12
UniProt

2
CCDS

CCDS48425.1, CCDS48426.1

Ensembl

ENSMUSG00000040723 (Evidence)
NCBI Gene

226594

			Length	Strain/Species	Flank
genomic	226594	NCBI Gene Model \| MGI Sequence Detail	61130	C57BL/6J	± kb
transcript	NM_178593	RefSeq \| MGI Sequence Detail	2670	C57BL/6
polypeptide	Q3UZA1	UniProt \| EBI \| MGI Sequence Detail	412	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013844 Capz-interacting protein

(term hierarchy)
InterPro Domains

IPR029341 FAM21/CAPZIP domain

IPR007850 RCSD
GlyGen

Q3UZA1 2 sites, 1 O-linked glycan (1 site)

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 2

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MGI:1925181

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:334527 Weiss AC, et al., Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Development. 2023 Mar 15;150(6):dev201048

TSS for Rcsd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14790	Chr1:165537347-165537363 (-)	277 bp
Tssr14789	Chr1:165537316-165537338 (-)	305 bp
Tssr14788	Chr1:165537287-165537311 (-)	333 bp
Tssr14787	Chr1:165537237-165537263 (-)	382 bp
Tssr14786	Chr1:165535657-165535668 (-)	1,969 bp
Tssr14785	Chr1:165535626-165535647 (-)	1,995 bp
Tssr14784	Chr1:165535578-165535598 (-)	2,044 bp
Tssr14783	Chr1:165535561-165535577 (-)	2,063 bp
Tssr14782	Chr1:165528560-165528573 (-)	9,065 bp
Tssr14781	Chr1:165528498-165528510 (-)	9,128 bp
Tssr14780	Chr1:165525027-165525035 (-)	12,601 bp
Tssr14779	Chr1:165524308-165524319 (-)	13,318 bp
Tssr14778	Chr1:165513090-165513094 (-)	24,540 bp
Tssr14777	Chr1:165506487-165506509 (-)	31,134 bp
Tssr14776	Chr1:165506391-165506412 (-)	31,230 bp
Tssr14775	Chr1:165485448-165485461 (-)	52,177 bp
Tssr14774	Chr1:165480150-165480159 (-)	57,477 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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