Nlrp9a Gene Detail

Summary

• Symbol
  Nlrp9a
• Name
  NLR family, pyrin domain containing 9A
• Synonyms
  D7Ertd565e, Nalp9a, Nalp-theta

• Feature Type
  protein coding gene
• IDs
  MGI:2675292
  NCBI Gene: 233001
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr7:26234448-26273573 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 15.08 cM, cytoband A3
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  1100 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675292	protein coding gene	Chr7:26234448-26275040 (+)
129S1/SvImJ	ENSMUSG00200040278	protein coding gene	Chr7:16028858-16069448 (+)
A/J	ENSMUSG00195051349	protein coding gene	Chr7:18681519-18728968 (+)
AKR/J	ENSMUSG00220049556	protein coding gene	Chr7:25707198-25754830 (-)
BALB/cJ	ENSMUSG00180051933	protein coding gene	Chr7:16746856-16794307 (+)
C3H/HeJ	ENSMUSG00175045231	protein coding gene	Chr7:17791708-17832298 (+)
C57BL/6NJ	ENSMUSG00215054223	protein coding gene	Chr7:16035083-16075677 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029388	protein coding gene	Chr7:25726255-25766097 (+)
CAST/EiJ	ENSTCUG00005047036	protein coding gene	Chr7:17746783-17786999 (+)
CBA/J	ENSMUSG00210051954	protein coding gene	Chr7:16977376-17017968 (+)
DBA/2J	ENSMUSG00185046119	protein coding gene	Chr7:20191335-20231916 (+)
FVB/NJ	ENSMUSG00205024119	protein coding gene	Chr7:16862123-16902717 (-)
JF1/MsJ	ENSUMUG00000039989	protein coding gene	Chr7:24523508-24564110 (+)
LP/J	ENSMUSG00230051656	protein coding gene	Chr7:25254897-25295485 (+)
NOD/ShiLtJ	ENSMUSG00190034863	protein coding gene	Chr7:16434780-16475368 (+)
NZO/HlLtJ	ENSMUSG00225025987	protein coding gene	Chr7:24133305-24173901 (+)
PWK/PhJ	ENSLUMG00010036750	protein coding gene	Chr7:16452381-16492967 (+)
SPRET/EiJ	ENSMSPG00010050033	protein coding gene	Chr7:15897865-15945004 (+)
WSB/EiJ	no annotation

Homology

• Human Ortholog
  NLRP9, NLR family pyrin domain containing 9

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  NLRP9, NLR family pyrin domain containing 9
  
• Synonyms
  CLR19.1, NALP9, NOD6, PAN12
• Links
  HGNC:22941

  NCBI Gene ID: 338321

  UniProt: Q7RTR0

  
  
• Chr Location
  19q13.42; chr19:55708438-55738402 (-)  GRCh38

---

• MGI Vertebrate Homology
  Nlrp9a stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: NLRP9
• Gene Tree
  Nlrp9a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from multigenic genotypes
  9 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  3
• Gene trapped
  1
• Targeted
  3
• Genomic Mutations
  2 involving Nlrp9a
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  73 strains or lines available

Mice homozygous for null alleles of Nlrp9a, Nlrp9b, and Nlrp9c exhibit reduced litter size, incomplete preimplantation lethality, delayed or impaired blastocyst formation, and failure of cell division at the 2 cell stage.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  5

Expression

• Assay Results
  597
• cDNA Data
  10
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  51
• RefSeq
  6
• UniProt
  5
• CCDS
  CCDS39844.1, CCDS39845.1

• Ensembl
  ENSMUSG00000054102 (Evidence)
• NCBI Gene
  233001

Representative Sequences			Length	Strain/Species
genomic	233001	NCBI Gene Model | MGI Sequence Detail	39126	C57BL/6J
transcript	NM_001048219	RefSeq | MGI Sequence Detail	3349	ZRU/MplStud
polypeptide	Q66X03	UniProt | EBI | MGI Sequence Detail	949	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000011568 NACHT, LRR and PYD domains-containing protein 9A
  (term hierarchy)
• InterPro Domains
  IPR004020 DAPIN domain
  IPR011029 Death-like domain superfamily
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain superfamily
  IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
  IPR007111 NACHT nucleoside triphosphatase
  IPR050637 NLRP family, innate immunity and inflammation regulators
  IPR041075 NOD1/2, winged helix domain
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• All nucleic 11

  cDNA 10

  Primer pair 1

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:1261858

References

• Summaries
  All 37

  Developmental Gene Expression 1

  Gene Ontology 5

  Phenotypes 9
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:386971 Tran LM, et al., Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis. 2026 Mar 19;