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Clec18a Gene Detail
Summary
  • Symbol
    Clec18a
  • Name
    C-type lectin domain family 18, member A
  • Synonyms
    Mrcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672935
    NCBI Gene: 353287
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111796128-111819056 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672935
 protein coding gene Chr8:111785552-111819058 (-)
129S1/SvImJ ENSMUSG00200013900
 protein coding gene Chr8:106089829-106123328 (-)
A/J ENSMUSG00195018253
 protein coding gene Chr8:106402441-106435939 (-)
AKR/J ENSMUSG00220015199
 protein coding gene Chr8:106544872-106578370 (-)
BALB/cJ ENSMUSG00180018810
 protein coding gene Chr8:106407588-106441042 (-)
C3H/HeJ ENSMUSG00175023903
 protein coding gene Chr8:106464762-106498254 (-)
C57BL/6NJ ENSMUSG00215035338
 protein coding gene Chr8:106067715-106101207 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031570
 protein coding gene Chr8:102152772-102185875 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210030154
 protein coding gene Chr8:106391899-106425395 (-)
DBA/2J ENSMUSG00185017264
 protein coding gene Chr8:112501010-112534506 (-)
FVB/NJ ENSMUSG00205022941
 protein coding gene Chr8:105404373-105437867 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230033799
 protein coding gene Chr8:116180800-116214298 (-)
NOD/ShiLtJ ENSMUSG00190024414
 protein coding gene Chr8:106542890-106576389 (-)
NZO/HlLtJ ENSMUSG00225021792
 protein coding gene Chr8:119531482-119564983 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CLEC18A, C-type lectin domain family 18 member A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC18A, C-type lectin domain family 18 member A
  • Synonyms
    MRCL, MRCL1, MRLP2
  • Links
    NCBI Gene ID: 348174
    UniProt: A5D8T8

  • Chr Location
    16q22.1; chr16:69943519-69966623 (+)  GRCh38
  • Human Ortholog
    CLEC18B, C-type lectin domain family 18 member B
  • Synonyms
    MRCL2
  • Links
    NCBI Gene ID: 497190
    UniProt: Q6UXF7

  • Chr Location
    16q23.1; chr16:74408631-74424249 (-)  GRCh38
  • Human Ortholog
    CLEC18C, C-type lectin domain family 18 member C
  • Synonyms
    MRCL, MRCL3
  • Links
    NCBI Gene ID: 283971
    UniProt: Q8NCF0

  • Chr Location
    16q22.1; chr16:70173322-70187361 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    4
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
  • All Sequences
    64
  • RefSeq
    22
  • UniProt
    4
Representative SequencesLengthStrain/SpeciesFlank
genomic 353287 NCBI Gene Model | MGI Sequence Detail 22929 C57BL/6J ±  kb
transcript NM_001402947 RefSeq | MGI Sequence Detail 2026 C57BL/6  
polypeptide Q7TSQ1 UniProt | EBI | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 3
    Primer pair 2
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:309008 Huang YL, et al., Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Commun Biol. 2021 Feb 18;4(1):229
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory