Clec18a MGI Mouse Gene Detail - MGI:2672935 - C-type lectin domain family 18, member A

Symbol

Clec18a
Name

C-type lectin domain family 18, member A
Synonyms

Mrcl

Feature Type

protein coding gene
IDs

MGI:2672935
NCBI Gene: 353287
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr8:111796128-111819056 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 57.93 cM
Mapping Data

1 experiment

SNPs within 2kb

69 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2672935	protein coding gene	Chr8:111785552-111819058 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034135	protein coding gene	Chr8:113778360-113824877 (-)
A/J	MGP_AJ_G0034114	protein coding gene	Chr8:109172595-109207577 (-)
AKR/J	MGP_AKRJ_G0034041	protein coding gene	Chr8:112363706-112404002 (-)
BALB/cJ	MGP_BALBcJ_G0034108	protein coding gene	Chr8:109351580-109384071 (-)
C3H/HeJ	MGP_C3HHeJ_G0033819	protein coding gene	Chr8:113087554-113125894 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034628	protein coding gene	Chr8:117778941-117818652 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031570	protein coding gene	Chr8:102152772-102185875 (-)
CAST/EiJ	MGP_CASTEiJ_G0033146	protein coding gene	Chr8:112702748-112741536 (-)
CBA/J	MGP_CBAJ_G0033793	protein coding gene	Chr8:121787028-121826728 (-)
DBA/2J	MGP_DBA2J_G0033948	protein coding gene	Chr8:108461238-108496981 (-)
FVB/NJ	MGP_FVBNJ_G0033892	protein coding gene	Chr8:107422800-107455090 (-)
LP/J	MGP_LPJ_G0034038	protein coding gene	Chr8:113964239-113998438 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033938	protein coding gene	Chr8:124678684-124718491 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034647	protein coding gene	Chr8:112337360-112377172 (-)
PWK/PhJ	MGP_PWKPhJ_G0032849	protein coding gene	Chr8:108043143-108075712 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032688	protein coding gene	Chr8:111017209-111052619 (-)
WSB/EiJ	MGP_WSBEiJ_G0033262	protein coding gene	Chr8:113022108-113057038 (-)

Human Ortholog

CLEC18A, C-type lectin domain family 18 member A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC18A, C-type lectin domain family 18 member A
Synonyms

MRCL, MRCL1, MRLP2
Links

HGNC:30388

NCBI Gene ID: 348174

neXtProt AC: NX_A5D8T8

UniProt: A5D8T8
Chr Location

16q22.1; chr16:69943519-69966623 (+) GRCh38

Human Ortholog

CLEC18B, C-type lectin domain family 18 member B
Synonyms

MRCL2
Links

HGNC:33849

NCBI Gene ID: 497190

neXtProt AC: NX_Q6UXF7

UniProt: Q6UXF7
Chr Location

16q23.1; chr16:74408631-74424249 (-) GRCh38

Human Ortholog

CLEC18C, C-type lectin domain family 18 member C
Synonyms

MRCL, MRCL3
Links

HGNC:28538

NCBI Gene ID: 283971

neXtProt AC: NX_Q8NCF0

UniProt: Q8NCF0
Chr Location

16q22.1; chr16:70173322-70187361 (+) GRCh38

Alliance of Genome Resources

Clec18a stringent orthology
3 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLEC18A, CLEC18B, CLEC18C
Gene Tree

Clec18a

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Clec18a interacts with 45 markers (Mir22, Mir29a, Mir33, ...) View All

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All Sequences

68
RefSeq

22
UniProt

4

Ensembl

ENSMUSG00000033633 (Evidence)
NCBI Gene

353287

			Length	Strain/Species	Flank
genomic	353287	NCBI Gene Model \| MGI Sequence Detail	22929	C57BL/6J	± kb
transcript	NM_001402947	RefSeq \| MGI Sequence Detail	2026	C57BL/6
polypeptide	Q7TSQ1	UniProt \| EBI \| MGI Sequence Detail	534	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR014044 CAP domain

IPR035940 CAP superfamily

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR001283 Cysteine-rich secretory protein-related

IPR000742 EGF-like domain

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 6
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:309008 Huang YL, et al., Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Commun Biol. 2021 Feb 18;4(1):229

TSS for Clec18a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82909	Chr8:111808675-111808710 (-)	10,363 bp
Tssr82908	Chr8:111808650-111808653 (-)	10,404 bp
Tssr82907	Chr8:111808530-111808548 (-)	10,517 bp
Tssr82906	Chr8:111808487-111808503 (-)	10,561 bp
Tssr82905	Chr8:111808464-111808475 (-)	10,586 bp
Tssr82904	Chr8:111808445-111808456 (-)	10,605 bp
Tssr82903	Chr8:111808367-111808372 (-)	10,686 bp
Tssr82902	Chr8:111808327-111808362 (-)	10,711 bp
Tssr82901	Chr8:111808302-111808311 (-)	10,749 bp
Tssr82900	Chr8:111807769-111807780 (-)	11,281 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/12/2023 MGI 6.22