Wfikkn1 MGI Mouse Gene Detail - MGI:2670967 - WAP, FS, Ig, KU, and NTR-containing protein 1

Symbol

Wfikkn1
Name

WAP, FS, Ig, KU, and NTR-containing protein 1
Synonyms

Gasp2

Feature Type

protein coding gene
IDs

MGI:2670967
NCBI Gene: 215001
Alliance

genome feature page

Sequence Map

Chr17:26096602-26099832 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.97 cM
Mapping Data

2 experiments

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670967	protein coding gene	Chr17:26096602-26099832 (-)
129S1/SvImJ	ENSMUSG00200045916	protein coding gene	Chr17:21541596-21544826 (-)
A/J	ENSMUSG00195054225	protein coding gene	Chr17:22558812-22562042 (-)
AKR/J	ENSMUSG00220051552	protein coding gene	Chr17:21605560-21608790 (-)
BALB/cJ	ENSMUSG00180049444	protein coding gene	Chr17:21839604-21842834 (-)
C3H/HeJ	ENSMUSG00175053531	protein coding gene	Chr17:21597844-21601074 (-)
C57BL/6NJ	ENSMUSG00215053124	protein coding gene	Chr17:21606190-21609420 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021262	protein coding gene	Chr17:21712417-21715073 (-)
CAST/EiJ	ENSTCUG00005046926	protein coding gene	Chr17:22187614-22190843 (-)
CBA/J	ENSMUSG00210049174	protein coding gene	Chr17:21436675-21439905 (-)
DBA/2J	ENSMUSG00185052383	protein coding gene	Chr17:23647063-23650293 (-)
FVB/NJ	ENSMUSG00205023667	protein coding gene	Chr17:21902755-21905985 (-)
JF1/MsJ	ENSUMUG00000046981	protein coding gene	Chr17:23102807-23106028 (-)
LP/J	ENSMUSG00230054573	protein coding gene	Chr17:25046131-25049361 (-)
NOD/ShiLtJ	ENSMUSG00190040455	protein coding gene	Chr17:21535779-21539009 (-)
NZO/HlLtJ	ENSMUSG00225053817	protein coding gene	Chr17:26966137-26969367 (-)
PWK/PhJ	ENSLUMG00010045432	protein coding gene	Chr17:21021930-21025151 (-)
SPRET/EiJ	ENSMSPG00010047475	protein coding gene	Chr17:22340254-22343485 (-)
WSB/EiJ	ENSIUOG00005050740	protein coding gene	Chr17:22279580-22282810 (-)

Human Ortholog

WFIKKN1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WFIKKN1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Synonyms

C16orf12, RJD2, WFDC20A, WFIKKN
Links

HGNC:30912

NCBI Gene ID: 117166

UniProt: Q96NZ8
Chr Location

16p13.3; chr16:629239-634117 (+) GRCh38

MGI Vertebrate Homology

Wfikkn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WFIKKN1
Gene Tree

Wfikkn1

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
10 phenotypes from multigenic genotypes
3 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Wfikkn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation show partial penetrance of posteriorly directed homeotic transformations throughout the axial skeleton, impaired muscle regeneration and a mild decrease in skeletal muscle weight in males.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

609
Tissues

12
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wfikkn1

ZFIN wfikkn1

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS50038.1

Ensembl

ENSMUSG00000071192 (Evidence)
NCBI Gene

215001

			Length	Strain/Species	Flank
genomic	215001	NCBI Gene Model \| MGI Sequence Detail	3231	C57BL/6J	± kb
transcript	NM_001100454	RefSeq \| MGI Sequence Detail	2536	Not Specified
polypeptide	Q8R0S6	UniProt \| EBI \| MGI Sequence Detail	552	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017412 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR036645 Elafin-like superfamily

IPR003599 Immunoglobulin domain subtype

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR001134 Netrin domain

IPR002223 Pancreatic trypsin inhibitor Kunitz domain

IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily

IPR020901 Proteinase inhibitor I2, Kunitz, conserved site

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

IPR008197 WAP-type 'four-disulfide core' domain

IPR033638 WFIKKN1/2, immunoglobulin-like domain 3
GlyGen

Q8R0S6 2 sites

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 7
Earliest

J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24