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Rtn4rl2 Gene Detail
Summary
  • Symbol
    Rtn4rl2
  • Name
    reticulon 4 receptor-like 2
  • Synonyms
    Ngr2, Ngrh1, Ngrl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669796
    NCBI Gene: 269295
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84702268-84717054 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669796
 protein coding gene Chr2:84701653-84718985 (-)
129S1/SvImJ ENSMUSG00200052328
 protein coding gene Chr2:81718797-81733587 (-)
A/J ENSMUSG00195050188
 protein coding gene Chr2:81831553-81846340 (-)
AKR/J ENSMUSG00220052244
 protein coding gene Chr2:81710278-81725062 (-)
BALB/cJ ENSMUSG00180054653
 protein coding gene Chr2:81759381-81774169 (-)
C3H/HeJ ENSMUSG00175051650
 protein coding gene Chr2:81898957-81913735 (-)
C57BL/6NJ ENSMUSG00215052939
 protein coding gene Chr2:81803921-81818712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023734
 protein coding gene Chr2:79091401-79106252 (-)
CAST/EiJ ENSTCUG00005051529
 protein coding gene Chr2:81249863-81264665 (-)
CBA/J ENSMUSG00210027366
 protein coding gene Chr2:81926871-81941650 (-)
DBA/2J ENSMUSG00185056652
 protein coding gene Chr2:81755632-81770415 (-)
FVB/NJ ENSMUSG00205047768
 protein coding gene Chr2:81142594-81157347 (-)
JF1/MsJ ENSUMUG00000004465
 protein coding gene Chr2:81681760-81696543 (-)
LP/J ENSMUSG00230040209
 protein coding gene Chr2:83506711-83521494 (-)
NOD/ShiLtJ ENSMUSG00190043302
 protein coding gene Chr2:81796215-81810993 (-)
NZO/HlLtJ ENSMUSG00225002056
 protein coding gene Chr2:91391352-91406131 (-)
PWK/PhJ ENSLUMG00010045247
 protein coding gene Chr2:81698299-81713060 (-)
SPRET/EiJ ENSMSPG00010051999
 protein coding gene Chr2:83597637-83612478 (-)
WSB/EiJ ENSIUOG00005053243
 protein coding gene Chr2:81735716-81750499 (-)



Homology
more
  • Human Ortholog
    RTN4RL2, reticulon 4 receptor like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN4RL2, reticulon 4 receptor like 2
  • Synonyms
    NgR2, NGRH1
  • Links
    NCBI Gene ID: 349667
    UniProt: Q86UN3

  • Chr Location
    11q12.1; chr11:57460528-57477534 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    78
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050896 Ensembl Gene Model | MGI Sequence Detail 14787 C57BL/6J ±  kb
    transcript ENSMUST00000151799 Ensembl | MGI Sequence Detail 1303 Not Applicable  
    polypeptide ENSMUSP00000118362 Ensembl | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014352 reticulon-4 receptor-like 2
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q7M6Z0 5 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:83107 Pignot V, et al., Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem. 2003 May;85(3):717-28
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory