Gpr142 MGI Mouse Gene Detail - MGI:2668437 - G protein-coupled receptor 142

Symbol

Gpr142
Name

G protein-coupled receptor 142

Feature Type

protein coding gene
IDs

MGI:2668437
NCBI Gene: 217302
Alliance

gene page

Sequence Map

Chr11:114689750-114697571 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.54 cM
Mapping Data

2 experiments

SNPs within 2kb

38 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2668437	protein coding gene	Chr11:114689750-114697571 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019361	protein coding gene	Chr11:118738871-118747996 (+)
A/J	MGP_AJ_G0019330	protein coding gene	Chr11:113577002-113584814 (+)
AKR/J	MGP_AKRJ_G0019298	protein coding gene	Chr11:116936370-116944178 (+)
BALB/cJ	MGP_BALBcJ_G0019303	protein coding gene	Chr11:113996284-114004663 (+)
C3H/HeJ	MGP_C3HHeJ_G0019112	protein coding gene	Chr11:117285593-117295294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019754	protein coding gene	Chr11:122303817-122311638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017377	protein coding gene	Chr11:110643602-110651378 (+)
CAST/EiJ	MGP_CASTEiJ_G0018666	protein coding gene	Chr11:118617126-118624948 (+)
CBA/J	MGP_CBAJ_G0019082	protein coding gene	Chr11:127191728-127203179 (+)
DBA/2J	MGP_DBA2J_G0019194	protein coding gene	Chr11:113019367-113026945 (+)
FVB/NJ	MGP_FVBNJ_G0019185	protein coding gene	Chr11:112502401-112509575 (+)
LP/J	MGP_LPJ_G0019264	protein coding gene	Chr11:119144285-119155399 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019216	protein coding gene	Chr11:126351612-126359485 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019791	protein coding gene	Chr11:117612490-117620897 (+)
PWK/PhJ	MGP_PWKPhJ_G0018431	protein coding gene	Chr11:114255407-114263357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018223	protein coding gene	Chr11:117417786-117425405 (+)
WSB/EiJ	MGP_WSBEiJ_G0018718	protein coding gene	Chr11:117569890-117580259 (+)

Human Ortholog

GPR142, G protein-coupled receptor 142

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR142, G protein-coupled receptor 142
Synonyms

GPRg1b, PGR2
Links

HGNC:20088

NCBI Gene ID: 350383

neXtProt AC: NX_Q7Z601

UniProt: Q7Z601
Chr Location

17q25.1; chr17:74367458-74372600 (+) GRCh38

MGI Vertebrate Homology

Gpr142 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR142
Gene Tree

Gpr142

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show alterations in gut and pancreatic islet hormone secretion and glucose homeostasis.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

35
cDNA Data

2
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

5
CCDS

CCDS25611.1, CCDS83922.1

Ensembl

ENSMUSG00000034677 (Evidence)
NCBI Gene

217302

			Length	Strain/Species	Flank
genomic	217302	NCBI Gene Model \| MGI Sequence Detail	7822	C57BL/6J	± kb
transcript	NM_001346772	RefSeq \| MGI Sequence Detail	1116	C57BL/6
polypeptide	Q7TQN9	UniProt \| EBI \| MGI Sequence Detail	365	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001508 probable G-protein coupled receptor 142

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 7

Genomic 2

cDNA 2

Primer pair 1

Other 2

Microarray probesets 1

Summaries

All 27

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 10
Earliest

J:106981 Susens U, et al., Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Neuropharmacology. 2006 Mar;50(4):512-20
Latest

J:319374 Rudenko O, et al., The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Mol Metab. 2019 Jan;19:49-64

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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