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Il22ra2 Gene Detail
Summary
  • Symbol
    Il22ra2
  • Name
    interleukin 22 receptor, alpha 2
  • Synonyms
    Il-22bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665114
    NCBI Gene: 237310
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19497776-19510429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 8.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2665114
protein coding gene Chr10:19497746-19510429 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017046
protein coding gene Chr10:17347063-17360664 (+)
A/J MGP_AJ_G0017024
protein coding gene Chr10:16691239-16704039 (+)
AKR/J MGP_AKRJ_G0016988
protein coding gene Chr10:16965967-16978648 (+)
BALB/cJ MGP_BALBcJ_G0016982
protein coding gene Chr10:16745981-16758620 (+)
C3H/HeJ MGP_C3HHeJ_G0016807
protein coding gene Chr10:17287109-17299760 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017444
protein coding gene Chr10:17767901-17780584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015149
protein coding gene Chr10:15697266-15710129 (+)
CAST/EiJ MGP_CASTEiJ_G0016389
protein coding gene Chr10:17165655-17177964 (+)
CBA/J MGP_CBAJ_G0016779
protein coding gene Chr10:18584382-18597041 (+)
DBA/2J MGP_DBA2J_G0016887
protein coding gene Chr10:16570229-16582888 (+)
FVB/NJ MGP_FVBNJ_G0016882
protein coding gene Chr10:16327070-16339753 (+)
LP/J MGP_LPJ_G0016962
protein coding gene Chr10:17153036-17165691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016912
protein coding gene Chr10:18830882-18844621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017482
protein coding gene Chr10:16951901-16964584 (+)
PWK/PhJ MGP_PWKPhJ_G0016174
protein coding gene Chr10:16441492-16453884 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015957
protein coding gene Chr10:17115364-17128214 (+)
WSB/EiJ MGP_WSBEiJ_G0016451
protein coding gene Chr10:17047188-17059849 (+)



Homology
more
  • Human Ortholog
    IL22RA2, interleukin 22 receptor subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL22RA2, interleukin 22 receptor subunit alpha 2
  • Synonyms
    CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22RA2, IL-22R-alpha-2, ZCYTOR16
  • Links
    NCBI Gene ID: 116379
    neXtProt AC: NX_Q969J5
    UniProt: Q969J5

  • Chr Location
    6q23.3; chr6:137143820-137173648 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237310 NCBI Gene Model | MGI Sequence Detail 12654 C57BL/6J ±  kb
    transcript NM_178258 RefSeq | MGI Sequence Detail 2468 C57BL/6  
    polypeptide Q80XF5 UniProt | EBI | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346205 Zhang Z, et al., IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury. Am J Pathol. 2024 Mar;194(3):338-352

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory