Fsip2 MGI Mouse Gene Detail - MGI:2664111 - fibrous sheath-interacting protein 2

Symbol

Fsip2
Name

fibrous sheath-interacting protein 2
Synonyms

OTTMUSG00000013335

Feature Type

protein coding gene
IDs

MGI:2664111
NCBI Gene: 241516
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:82773978-82839281 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.08 cM
Mapping Data

1 experiment

SNPs within 2kb

1403 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2664111	protein coding gene	Chr2:82773978-82839281 (+)
129S1/SvImJ	ENSMUSG00200003167	protein coding gene	Chr2:79828677-79893987 (+)
A/J	ENSMUSG00195019586	protein coding gene	Chr2:79981670-80046961 (+)
AKR/J	ENSMUSG00220001878	protein coding gene	Chr2:79867308-79932600 (+)
BALB/cJ	ENSMUSG00180006136	protein coding gene	Chr2:79909584-79974878 (+)
C3H/HeJ	ENSMUSG00175010183	protein coding gene	Chr2:80037168-80102459 (+)
C57BL/6NJ	ENSMUSG00215022840	protein coding gene	Chr2:79905655-79970963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023712	protein coding gene	Chr2:77405277-77469724 (+)
CAST/EiJ	ENSTCUG00005028227	protein coding gene	Chr2:79358470-79430068 (+)
CBA/J	ENSMUSG00210001796	protein coding gene	Chr2:80071272-80136548 (+)
DBA/2J	ENSMUSG00185011321	protein coding gene	Chr2:79905868-79971160 (+)
FVB/NJ	ENSMUSG00205018233	protein coding gene	Chr2:79238648-79303953 (+)
JF1/MsJ	ENSUMUG00000018504	protein coding gene	Chr2:79584457-79649833 (+)
LP/J	ENSMUSG00230023721	protein coding gene	Chr2:81650394-81715687 (+)
NOD/ShiLtJ	ENSMUSG00190010022	protein coding gene	Chr2:79915316-79980684 (+)
NZO/HlLtJ	ENSMUSG00225002101	protein coding gene	Chr2:89488483-89553786 (+)
PWK/PhJ	ENSLUMG00010029681	protein coding gene	Chr2:79762821-79828186 (+)
SPRET/EiJ	ENSMSPG00010018901	protein coding gene	Chr2:81128874-81193607 (+)
WSB/EiJ	ENSIUOG00005010855	protein coding gene	Chr2:75908580-75972279 (-)

Human Ortholog

FSIP2, fibrous sheath interacting protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSIP2, fibrous sheath interacting protein 2
Synonyms

SPGF34
Links

HGNC:21675

NCBI Gene ID: 401024

UniProt: Q5CZC0
Chr Location

2q32.1; chr2:185737134-185833290 (+) GRCh38

MGI Vertebrate Homology

Fsip2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FSIP2
Gene Tree

Fsip2

Diseases

1 with human FSIP2 associations

				Human Disease	Mouse Models
				spermatogenic failure 34 IDs spermatogenic failure 34 DOID:0111911 OMIM:618153

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Transgenic

1
Genomic Mutations

3 involving Fsip2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

333 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout leads to male sterility owing to sperm flagellum anomalies caused by the absence of the fibrous sheath.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

4

Ensembl

ENSMUSG00000075249 (Evidence)
NCBI Gene

241516

			Length	Strain/Species	Flank
genomic	241516	NCBI Gene Model \| MGI Sequence Detail	65304	C57BL/6J	± kb
transcript	NM_001370266	RefSeq \| MGI Sequence Detail	21110	C57BL/6
polypeptide	A2ARZ3	UniProt \| EBI \| MGI Sequence Detail	6995	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007684 fibrous sheath-interacting protein 2

(term hierarchy)
InterPro Domains

IPR038891 Fibrous sheath-interacting protein 2

IPR031554 Fibrous sheath-interacting protein 2, C-terminal
GlyGen

A2ARZ3 7 sites, 1 O-linked glycan (7 sites)

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All nucleic 2

Genomic 2

Microarray probesets 3

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MGI:3782915

Summaries

All 23

Gene Ontology 4

Phenotypes 7
Earliest

J:83525 Brown PR, et al., A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003 Jun;68(6):2241-8
Latest

J:307606 Fang X, et al., Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation. Development. 2021 Jun 1;148(11):dev199216

TSS for Fsip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18638	Chr2:82773971-82773984 (+)	0 bp
Tssr549	Chr2:82822009-82822012 (+)	48,033 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24