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Snx13 Gene Detail
Summary
  • Symbol
    Snx13
  • Name
    sorting nexin 13
  • Synonyms
    mKIAA0713, RGS-PX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661416
    NCBI Gene: 217463
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:35097191-35197479 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 15.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661416
protein coding gene Chr12:35097185-35197479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019683
protein coding gene Chr12:33208329-33310652 (+)
A/J MGP_AJ_G0019649
protein coding gene Chr12:32196454-32298370 (+)
AKR/J MGP_AKRJ_G0019620
protein coding gene Chr12:33195496-33292928 (+)
BALB/cJ MGP_BALBcJ_G0019627
protein coding gene Chr12:32382667-32489237 (+)
C3H/HeJ MGP_C3HHeJ_G0019431
protein coding gene Chr12:33101813-33220632 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020074
protein coding gene Chr12:34165804-34271480 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017699
protein coding gene Chr12:31351545-31447454 (+)
CAST/EiJ MGP_CASTEiJ_G0018985
protein coding gene Chr12:28154501-28263672 (+)
CBA/J MGP_CBAJ_G0019403
protein coding gene Chr12:35274263-35396354 (+)
DBA/2J MGP_DBA2J_G0019516
protein coding gene Chr12:32020269-32125476 (+)
FVB/NJ MGP_FVBNJ_G0019505
protein coding gene Chr12:31750470-31852809 (+)
LP/J MGP_LPJ_G0019586
protein coding gene Chr12:33275881-33377576 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019541
protein coding gene Chr12:34983244-35088238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020114
protein coding gene Chr12:32699475-32801375 (+)
PWK/PhJ MGP_PWKPhJ_G0018752
protein coding gene Chr12:26740421-26841874 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018541
protein coding gene Chr12:27368716-27462880 (+)
WSB/EiJ MGP_WSBEiJ_G0019035
protein coding gene Chr12:32956947-33061893 (+)



Homology
more
  • Human Ortholog
    SNX13, sorting nexin 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX13, sorting nexin 13
  • Synonyms
    RGS-PX1
  • Links
    NCBI Gene ID: 23161
    neXtProt AC: NX_Q9Y5W8
    UniProt: Q9Y5W8

  • Chr Location
    7p21.1; chr7:17790761-17940501 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are growth retarded and die at midgestation with defects in neural tube closure, vasculogenesis and placental development. Mutant visceral yolk sac endoderm cells exhibit altered endocytic compartments, abundant autophagic vacuoles and mislocalization of endocytic markers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217463 NCBI Gene Model | MGI Sequence Detail 100289 C57BL/6J ±  kb
    transcript NM_001408821 RefSeq | MGI Sequence Detail 6461 C57BL/6  
    polypeptide Q6PHS6 UniProt | EBI | MGI Sequence Detail 957 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory