Actr3b MGI Mouse Gene Detail - MGI:2661120 - ARP3 actin-related protein 3B

Symbol

Actr3b
Name

ARP3 actin-related protein 3B
Synonyms

ARP11, Arp3b

Feature Type

protein coding gene
IDs

MGI:2661120
NCBI Gene: 242894
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:25964995-26055686 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 12.35 cM
Mapping Data

2 experiments

SNPs within 2kb

701 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661120	protein coding gene	Chr5:25964941-26055689 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029364	protein coding gene	Chr5:23589687-23689940 (+)
A/J	MGP_AJ_G0029330	protein coding gene	Chr5:22746060-22835141 (+)
AKR/J	MGP_AKRJ_G0029281	protein coding gene	Chr5:23686100-23780535 (+)
BALB/cJ	MGP_BALBcJ_G0029341	protein coding gene	Chr5:23259098-23347641 (+)
C3H/HeJ	MGP_C3HHeJ_G0029061	protein coding gene	Chr5:23779741-23875334 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029794	protein coding gene	Chr5:25116737-25219215 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027032	protein coding gene	Chr5:20659306-20677504 (+)
CAST/EiJ	MGP_CASTEiJ_G0028473	protein coding gene	Chr5:22995165-23093921 (+)
CBA/J	MGP_CBAJ_G0029028	protein coding gene	Chr5:25576676-25679511 (+)
DBA/2J	MGP_DBA2J_G0029179	protein coding gene	Chr5:23015470-23108696 (+)
FVB/NJ	MGP_FVBNJ_G0029137	protein coding gene	Chr5:22400165-22489910 (+)
LP/J	MGP_LPJ_G0029263	protein coding gene	Chr5:23982338-24083084 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029166	protein coding gene	Chr5:26630567-26732099 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029828	protein coding gene	Chr5:23298291-23389195 (+)
PWK/PhJ	MGP_PWKPhJ_G0028197	protein coding gene	Chr5:22150446-22246485 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028028	protein coding gene	Chr5:22653302-22752168 (+)
WSB/EiJ	MGP_WSBEiJ_G0028553	protein coding gene	Chr5:23385706-23481587 (+)

Human Ortholog

ACTR3B, actin related protein 3B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACTR3B, actin related protein 3B
Synonyms

ARP11, ARP3BETA
Links

HGNC:17256

NCBI Gene ID: 57180

neXtProt AC: NX_Q9P1U1

UniProt: Q9P1U1
Chr Location

7q36.1-q36.2; chr7:152759749-152855378 (+) GRCh38

Alliance of Genome Resources

Actr3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACTR3B
Gene Tree

Actr3b

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

2
Spontaneous

1
Genomic Mutations

5 involving Actr3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

3
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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Actr3b interacts with 74 markers (Mir23a, Mir23b, Mir26a-1, ...) View All

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All Sequences

45
RefSeq

12
UniProt

1
CCDS

CCDS19136.1, CCDS80232.1

Ensembl

ENSMUSG00000056367 (Evidence)
NCBI Gene

242894

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056367	Ensembl Gene Model \| MGI Sequence Detail	90692	C57BL/6J	± kb
transcript	ENSMUST00000088244	Ensembl \| MGI Sequence Detail	1712	Not Applicable
polypeptide	ENSMUSP00000085578	Ensembl \| MGI Sequence Detail	418	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003697 actin-related protein 3B

(term hierarchy)
InterPro Domains

IPR020902 Actin/actin-like conserved site

IPR004000 Actin family

IPR043129 ATPase, nucleotide binding domain

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:2141129

Summaries

All 39

Developmental Gene Expression 2

Diseases 1

Gene Ontology 2

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

TSS for Actr3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45474	Chr5:25964938-25964982 (+)	-35 bp
Tssr45475	Chr5:25964985-25965042 (+)	19 bp
Tssr45476	Chr5:25973500-25973513 (+)	8,512 bp
Tssr45478	Chr5:26053308-26053323 (+)	88,321 bp
Tssr45479	Chr5:26053353-26053362 (+)	88,363 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/12/2023 MGI 6.22