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Ang4 Gene Detail
Summary
  • Symbol
    Ang4
  • Name
    angiogenin, ribonuclease A family, member 4
  • Synonyms
    Rnase5d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2656551
    NCBI Gene: 219033
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52001349-52011047 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.66 cM, cytoband B-C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2656551
 protein coding gene Chr14:52001335-52011047 (-)
129S1/SvImJ ENSMUSG00200016181
 protein coding gene Chr14:40803659-40813139 (-)
A/J ENSMUSG00195020931
 protein coding gene Chr14:41032748-41136110 (-)
AKR/J ENSMUSG00220037400
 protein coding gene Chr14:40388732-40492004 (-)
BALB/cJ ENSMUSG00180043320
 protein coding gene Chr14:40661730-40765097 (-)
C3H/HeJ ENSMUSG00175049026
 protein coding gene Chr14:42315949-42419296 (-)
C57BL/6NJ ENSMUSG00215017478
 protein coding gene Chr14:41007899-41017611 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005045744
 protein coding gene Chr14:42869760-42973863 (-)
CBA/J ENSMUSG00210033531
 protein coding gene Chr14:41015392-41118750 (-)
DBA/2J no annotation
FVB/NJ ENSMUSG00205044028
 protein coding gene Chr14:40271781-40344243 (-)
JF1/MsJ ENSUMUG00000038873
 protein coding gene Chr14:57844347-57854064 (-)
LP/J ENSMUSG00230052303
 protein coding gene Chr14:58178231-58281583 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225049624
 protein coding gene Chr14:48476312-48579667 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010042274
 protein coding gene Chr14:43939618-44011174 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ANG, angiogenin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANG, angiogenin
  • Synonyms
    ALS9, HEL168, RAA1, RNASE4, RNASE5
  • Links
    NCBI Gene ID: 283
    UniProt: P03950

  • Chr Location
    14q11.2; chr14:20682950-20698971 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human ANG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    19
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 219033 NCBI Gene Model | MGI Sequence Detail 9699 C57BL/6J ±  kb
transcript NM_177544 RefSeq | MGI Sequence Detail 695 C57BL/6  
polypeptide Q3TMQ6 UniProt | EBI | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:82368 Hooper LV, et al., Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003 Mar;4(3):269-73
  • Latest
    J:333936 Hu A, et al., Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model. PLoS One. 2023;18(3):e0281529
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory