Tbc1d16 MGI Mouse Gene Detail - MGI:2652878 - TBC1 domain family, member 16

Symbol

Tbc1d16
Name

TBC1 domain family, member 16

Feature Type

protein coding gene
IDs

MGI:2652878
NCBI Gene: 207592
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:119033871-119119325 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.34 cM
Mapping Data

1 experiment

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652878	protein coding gene	Chr11:119033869-119119354 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019475	protein coding gene	Chr11:123499179-123591813 (-)
A/J	MGP_AJ_G0019443	protein coding gene	Chr11:118039139-118126060 (-)
AKR/J	MGP_AKRJ_G0019413	protein coding gene	Chr11:121600469-121687456 (-)
BALB/cJ	MGP_BALBcJ_G0019418	protein coding gene	Chr11:118399189-118486130 (-)
C3H/HeJ	MGP_C3HHeJ_G0019224	protein coding gene	Chr11:121912704-122001844 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019867	protein coding gene	Chr11:127265239-127355190 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017492	protein coding gene	Chr11:115035793-115123772 (-)
CAST/EiJ	MGP_CASTEiJ_G0018778	protein coding gene	Chr11:123360472-123453699 (-)
CBA/J	MGP_CBAJ_G0019195	protein coding gene	Chr11:132205932-132303031 (-)
DBA/2J	MGP_DBA2J_G0019307	protein coding gene	Chr11:117415542-117501522 (-)
FVB/NJ	MGP_FVBNJ_G0019299	protein coding gene	Chr11:117076788-117167247 (-)
LP/J	MGP_LPJ_G0019377	protein coding gene	Chr11:123816778-123910091 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019332	protein coding gene	Chr11:131166733-131256240 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019906	protein coding gene	Chr11:122270161-122358716 (-)
PWK/PhJ	MGP_PWKPhJ_G0018544	protein coding gene	Chr11:118819282-118906316 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018336	protein coding gene	Chr11:122015855-122106961 (-)
WSB/EiJ	MGP_WSBEiJ_G0018830	protein coding gene	Chr11:122235599-122325481 (-)

Human Ortholog

TBC1D16, TBC1 domain family member 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D16, TBC1 domain family member 16
Links

HGNC:28356

NCBI Gene ID: 125058

neXtProt AC: NX_Q8TBP0

UniProt: Q8TBP0
Chr Location

17q25.3; chr17:79932343-80035872 (-) GRCh38

MGI Vertebrate Homology

Tbc1d16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D16
Gene Tree

Tbc1d16

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

104

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d16

ZFIN tbc1d16

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All Sequences

61
RefSeq

20
UniProt

4
CCDS

CCDS25711.1, CCDS83940.1

Ensembl

ENSMUSG00000039976 (Evidence)
NCBI Gene

207592

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039976	Ensembl Gene Model \| MGI Sequence Detail	85455	C57BL/6J	± kb
transcript	ENSMUST00000036113	Ensembl \| MGI Sequence Detail	6986	Not Applicable
polypeptide	ENSMUSP00000048516	Ensembl \| MGI Sequence Detail	766	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

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All nucleic 104

cDNA 104

Microarray probesets 3

Summaries

All 26

Gene Ontology 2

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

TSS for Tbc1d16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112214	Chr11:119119287-119119330 (-)	16 bp
Tssr112213	Chr11:119119282-119119285 (-)	41 bp
Tssr112212	Chr11:119077325-119077374 (-)	41,975 bp
Tssr112211	Chr11:119061796-119061839 (-)	57,507 bp
Tssr112210	Chr11:119042085-119042119 (-)	77,223 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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