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Arhgap32 Gene Detail
Summary
  • Symbol
    Arhgap32
  • Name
    Rho GTPase activating protein 32
  • Synonyms
    3426406O18Rik, GC-GAP, Grit, p200RhoGAP, PX-RICS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450166
    NCBI Gene: 330914
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:32027432-32179742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3440 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450166
 protein coding gene Chr9:31927921-32179742 (+)
129S1/SvImJ ENSMUSG00200007963
 protein coding gene Chr9:29027281-29179668 (+)
A/J ENSMUSG00195006114
 protein coding gene Chr9:28839360-28991765 (+)
AKR/J ENSMUSG00220010386
 protein coding gene Chr9:28869115-29021536 (+)
BALB/cJ ENSMUSG00180006219
 protein coding gene Chr9:28967789-29120196 (+)
C3H/HeJ ENSMUSG00175018965
 protein coding gene Chr9:28953570-29105971 (+)
C57BL/6NJ ENSMUSG00215007655
 protein coding gene Chr9:28924206-29076643 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031942
 protein coding gene Chr9:27887623-28038628 (+)
CAST/EiJ ENSTCUG00005018427
 protein coding gene Chr9:28924843-29078752 (+)
CBA/J ENSMUSG00210022104
 protein coding gene Chr9:28973451-29125784 (+)
DBA/2J ENSMUSG00185002333
 protein coding gene Chr9:29026393-29178742 (+)
FVB/NJ ENSMUSG00205003954
 protein coding gene Chr9:29327026-29479435 (+)
JF1/MsJ ENSUMUG00000011743
 protein coding gene Chr9:29212596-29368789 (+)
LP/J ENSMUSG00230004301
 protein coding gene Chr9:29455378-29612480 (+)
NOD/ShiLtJ ENSMUSG00190005776
 protein coding gene Chr9:29059936-29212306 (+)
NZO/HlLtJ ENSMUSG00225014595
 protein coding gene Chr9:29436496-29588888 (+)
PWK/PhJ ENSLUMG00010008848
 protein coding gene Chr9:29069402-29224245 (+)
SPRET/EiJ ENSMSPG00010002010
 protein coding gene Chr9:29451961-29597805 (+)
WSB/EiJ ENSIUOG00005015125
 protein coding gene Chr9:28502785-28655324 (+)



Homology
more
  • Human Ortholog
    ARHGAP32, Rho GTPase activating protein 32
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP32, Rho GTPase activating protein 32
  • Synonyms
    GC-GAP, GRIT, p200RhoGAP, p250GAP, PX-RICS, RICS
  • Links
    NCBI Gene ID: 9743
    UniProt: A7KAX9

  • Chr Location
    11q24.3; chr11:128965060-129279632 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arhgap32 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are fertile but display abnormal neurite growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    656
  • Tissues
    18
  • cDNA Data
    35
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041444 Ensembl Gene Model | MGI Sequence Detail 152311 C57BL/6J ±  kb
transcript ENSMUST00000174641 Ensembl | MGI Sequence Detail 13568 Not Applicable  
polypeptide ENSMUSP00000133898 Ensembl | MGI Sequence Detail 2089 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013998 rho/Cdc42/Rac GTPase-activating protein RICS
    (term hierarchy)
  • InterPro Domains
    IPR051576 PX domain-containing Rho GTPase-activating protein
    IPR036871 PX domain superfamily
    IPR042139 Rho GTPase-activating protein 32, PX domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001452 SH3 domain
    IPR036028 SH3-like domain superfamily
  • GlyGen
    Q811P8 13 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (10 sites)
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35
    Antibodies 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917927
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory