Fbxl16 MGI Mouse Gene Detail - MGI:2448488 - F-box and leucine-rich repeat protein 16

Symbol

Fbxl16
Name

F-box and leucine-rich repeat protein 16

Feature Type

protein coding gene
IDs

MGI:2448488
NCBI Gene: 214931
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:26028059-26040229 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.91 cM
Mapping Data

1 experiment

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448488	protein coding gene	Chr17:26027435-26040236 (+)
129S1/SvImJ	ENSMUSG00200045940	protein coding gene	Chr17:21473043-21485221 (+)
A/J	ENSMUSG00195052164	protein coding gene	Chr17:22490241-22502415 (+)
AKR/J	ENSMUSG00220053120	protein coding gene	Chr17:21536986-21549169 (+)
BALB/cJ	ENSMUSG00180046436	protein coding gene	Chr17:21771044-21783228 (+)
C3H/HeJ	ENSMUSG00175053631	protein coding gene	Chr17:21529296-21541473 (+)
C57BL/6NJ	ENSMUSG00215052806	protein coding gene	Chr17:21537636-21549811 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021252	protein coding gene	Chr17:21643638-21655873 (+)
CAST/EiJ	ENSTCUG00005045797	protein coding gene	Chr17:22119168-22131337 (+)
CBA/J	ENSMUSG00210049031	protein coding gene	Chr17:21368137-21380314 (+)
DBA/2J	ENSMUSG00185038864	protein coding gene	Chr17:23578506-23590680 (+)
FVB/NJ	ENSMUSG00205021844	protein coding gene	Chr17:21833950-21846133 (+)
JF1/MsJ	ENSUMUG00000054321	protein coding gene	Chr17:23033845-23046023 (+)
LP/J	ENSMUSG00230054466	protein coding gene	Chr17:24977576-24989758 (+)
NOD/ShiLtJ	ENSMUSG00190053994	protein coding gene	Chr17:21467224-21479396 (+)
NZO/HlLtJ	ENSMUSG00225051295	protein coding gene	Chr17:26897574-26909747 (+)
PWK/PhJ	ENSLUMG00010052971	protein coding gene	Chr17:20952941-20965082 (+)
SPRET/EiJ	ENSMSPG00010046994	protein coding gene	Chr17:22271834-22284059 (+)
WSB/EiJ	ENSIUOG00005043727	protein coding gene	Chr17:22210941-22223104 (+)

Human Ortholog

FBXL16, F-box and leucine rich repeat protein 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL16, F-box and leucine rich repeat protein 16
Synonyms

C16orf22, c380A1.1, Fbl16
Links

HGNC:14150

NCBI Gene ID: 146330

UniProt: Q8N461
Chr Location

16p13.3; chr16:692498-705843 (-) GRCh38

MGI Vertebrate Homology

Fbxl16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FBXL16
Gene Tree

Fbxl16

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Fbxl16
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

34
cDNA Data

21
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl16

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All Sequences

41
RefSeq

6
UniProt

3
CCDS

CCDS50036.1

Ensembl

ENSMUSG00000025738 (Evidence)
NCBI Gene

214931

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025738	Ensembl Gene Model \| MGI Sequence Detail	12171	C57BL/6J	± kb
transcript	ENSMUST00000236165	Ensembl \| MGI Sequence Detail	2757	Not Applicable
polypeptide	ENSMUSP00000157536	Ensembl \| MGI Sequence Detail	479	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007374 F-box/LRR-repeat protein 16

(term hierarchy)
InterPro Domains

IPR050648 F-box/Leucine-rich repeat

IPR036047 F-box-like domain superfamily

IPR057207 F-box/LRR-repeat protein 15-like, leucin rich repeat domain

IPR001611 Leucine-rich repeat

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily
GlyGen

A2RT62 2 sites, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 14
Earliest

J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxl16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143181	Chr17:26027986-26028006 (+)	-63 bp
Tssr143182	Chr17:26028064-26028145 (+)	46 bp
Tssr143183	Chr17:26033116-26033121 (+)	5,060 bp
Tssr143184	Chr17:26036893-26036912 (+)	8,844 bp
Tssr143185	Chr17:26038797-26038809 (+)	10,744 bp
Tssr143186	Chr17:26039127-26039152 (+)	11,081 bp
Tssr143187	Chr17:26039353-26039367 (+)	11,301 bp
Tssr143188	Chr17:26039627-26039649 (+)	11,579 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24