Yeats2 MGI Mouse Gene Detail - MGI:2447762

Symbol

Yeats2
Name

YEATS domain containing 2

Feature Type

protein coding gene
IDs

MGI:2447762
NCBI Gene: 208146
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:19959813-20051323 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.37 cM
Mapping Data

2 experiments

SNPs within 2kb

350 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447762	protein coding gene	Chr16:19959803-20051323 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0022599	protein coding gene	Chr16:16612956-16704517 (+)
AKR/J	MGP_AKRJ_G0022574	protein coding gene	Chr16:17247815-17342203 (+)
BALB/cJ	MGP_BALBcJ_G0022603	protein coding gene	Chr16:16759986-16851458 (+)
C3H/HeJ	MGP_C3HHeJ_G0022368	protein coding gene	Chr16:17410159-17503882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023054	protein coding gene	Chr16:17784659-17876435 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020571	protein coding gene	Chr16:17300786-17396134 (+)
CAST/EiJ	MGP_CASTEiJ_G0021898	protein coding gene	Chr16:17389151-17481345 (+)
CBA/J	MGP_CBAJ_G0022340	protein coding gene	Chr16:18507796-18604337 (+)
DBA/2J	MGP_DBA2J_G0022472	protein coding gene	Chr16:16542350-16634455 (+)
FVB/NJ	MGP_FVBNJ_G0022447	protein coding gene	Chr16:16572409-16665996 (+)
LP/J	MGP_LPJ_G0022539	protein coding gene	Chr16:17189146-17284193 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022467	protein coding gene	Chr16:18206124-18311756 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023065	protein coding gene	Chr16:17198044-17292930 (+)
PWK/PhJ	MGP_PWKPhJ_G0021639	protein coding gene	Chr16:16786562-16880715 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021468	protein coding gene	Chr16:16999809-17094471 (+)
WSB/EiJ	MGP_WSBEiJ_G0021942	protein coding gene	Chr16:17196152-17291566 (+)

Human Ortholog

YEATS2, YEATS domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YEATS2, YEATS domain containing 2
Synonyms

FAME4
Links

HGNC:25489

NCBI Gene ID: 55689

neXtProt AC: NX_Q9ULM3

UniProt: Q9ULM3
Chr Location

3q27.1; chr3:183697797-183812624 (+) GRCh38

MGI Vertebrate Homology

Yeats2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YEATS2
Gene Tree

Yeats2

Diseases

1 with human YEATS2 associations

				Human Disease	Mouse Models
				familial adult myoclonic epilepsy 4 IDs familial adult myoclonic epilepsy 4 DOID:0111693 OMIM:615127

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

86 strains or lines available

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

134

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase yeats2

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All Sequences

88
RefSeq

30
UniProt

6
CCDS

CCDS28043.1, CCDS49790.1

Ensembl

ENSMUSG00000041215 (Evidence)
NCBI Gene

208146

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041215	Ensembl Gene Model \| MGI Sequence Detail	91511	C57BL/6J	± kb
transcript	ENSMUST00000115560	Ensembl \| MGI Sequence Detail	6112	Not Applicable
polypeptide	ENSMUSP00000111222	Ensembl \| MGI Sequence Detail	1407	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000028952 YEATS domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR005033 YEATS

IPR038704 YEATS superfamily

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All nucleic 134

cDNA 134

Microarray probesets 2

Summaries

All 38

Gene Ontology 9

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Yeats2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137423	Chr16:19959811-19959890 (+)	38 bp
Tssr4810	Chr16:19993481-19993503 (+)	33,679 bp
Tssr137424	Chr16:20005260-20005269 (+)	45,452 bp
Tssr137425	Chr16:20005294-20005299 (+)	45,484 bp
Tssr137426	Chr16:20005322-20005327 (+)	45,512 bp
Tssr137427	Chr16:20007541-20007552 (+)	47,734 bp
Tssr137428	Chr16:20007559-20007561 (+)	47,747 bp
Tssr137429	Chr16:20007572-20007581 (+)	47,764 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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