Vgll2 MGI Mouse Gene Detail - MGI:2447460 - vestigial like family member 2

Symbol

Vgll2
Name

vestigial like family member 2
Synonyms

C130057C21Rik, Vgl-2, Vito1, VITO-1

Feature Type

protein coding gene
IDs

MGI:2447460
NCBI Gene: 215031
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:51898598-51904567 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 26.16 cM
Mapping Data

1 experiment

SNPs within 2kb

222 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447460	protein coding gene	Chr10:51898598-51904567 (+)
129S1/SvImJ	ENSMUSG00200006655	protein coding gene	Chr10:48787602-48793527 (+)
A/J	ENSMUSG00195002658	protein coding gene	Chr10:49063063-49069034 (+)
AKR/J	ENSMUSG00220005584	protein coding gene	Chr10:48745708-48751683 (+)
BALB/cJ	ENSMUSG00180011406	protein coding gene	Chr10:49192702-49198671 (+)
C3H/HeJ	ENSMUSG00175009766	protein coding gene	Chr10:48933878-48939847 (+)
C57BL/6NJ	ENSMUSG00215002009	protein coding gene	Chr10:48697769-48703738 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015310	protein coding gene	Chr10:46919607-46925538 (+)
CAST/EiJ	ENSTCUG00005008162	protein coding gene	Chr10:48919011-48924951 (+)
CBA/J	ENSMUSG00210008119	protein coding gene	Chr10:48839692-48845661 (+)
DBA/2J	ENSMUSG00185003038	protein coding gene	Chr10:48993255-48999230 (+)
FVB/NJ	ENSMUSG00205004644	protein coding gene	Chr10:48908978-48914949 (+)
JF1/MsJ	ENSUMUG00000025664	protein coding gene	Chr10:48678180-48684173 (+)
LP/J	ENSMUSG00230021705	protein coding gene	Chr10:50794776-50800703 (+)
NOD/ShiLtJ	ENSMUSG00190005425	protein coding gene	Chr10:49159317-49165288 (+)
NZO/HlLtJ	ENSMUSG00225022309	protein coding gene	Chr10:55075672-55081597 (+)
PWK/PhJ	ENSLUMG00010004296	protein coding gene	Chr10:48813255-48819236 (+)
SPRET/EiJ	ENSMSPG00010012128	protein coding gene	Chr10:50161302-50166847 (+)
WSB/EiJ	ENSIUOG00005014782	protein coding gene	Chr10:48804719-48810694 (+)

Human Ortholog

VGLL2, vestigial like family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VGLL2, vestigial like family member 2
Synonyms

VGL2, VITO1
Links

HGNC:20232

NCBI Gene ID: 245806

UniProt: Q8N8G2
Chr Location

6q22.1; chr6:117265558-117273630 (+) GRCh38

MGI Vertebrate Homology

Vgll2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VGLL2
Gene Tree

Vgll2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Vgll2
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal skeletal muscle fiber type ratio and impaired exercise endurance.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

68
cDNA Data

5
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vgll2

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS23837.1, CCDS78812.1

Ensembl

ENSMUSG00000049641 (Evidence)
NCBI Gene

215031

			Length	Strain/Species	Flank
genomic	215031	NCBI Gene Model \| MGI Sequence Detail	5970	C57BL/6J	± kb
transcript	NM_153786	RefSeq \| MGI Sequence Detail	1667	C57BL/6
polypeptide	Q8BGW8	UniProt \| EBI \| MGI Sequence Detail	322	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017291 transcription cofactor vestigial-like protein 2

(term hierarchy)
InterPro Domains

IPR011520 Vestigial family
GlyGen

Q8BGW8 1 site

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All nucleic 13

Genomic 1

cDNA 6

Primer pair 3

Other 3

Microarray probesets 1

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MGI:2443345

Summaries

All 42

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539

TSS for Vgll2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93295	Chr10:51898616-51898630 (+)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24