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Slc24a4 Gene Detail
Summary
  • Symbol
    Slc24a4
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
  • Synonyms
    A930002M03Rik, NCKX4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447362
    NCBI Gene: 238384
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102094992-102233350 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.42 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3962 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447362
protein coding gene Chr12:102094986-102239562 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020029
protein coding gene Chr12:103746052-103893006 (+)
A/J MGP_AJ_G0019985
protein coding gene Chr12:99755150-99899274 (+)
AKR/J MGP_AKRJ_G0019961
protein coding gene Chr12:102601293-102742913 (+)
BALB/cJ MGP_BALBcJ_G0019971
protein coding gene Chr12:100101192-100241042 (+)
C3H/HeJ MGP_C3HHeJ_G0019773
protein coding gene Chr12:103049560-103199549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020420
protein coding gene Chr12:106996133-107141831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018033
protein coding gene Chr12:96787796-96927615 (+)
CAST/EiJ MGP_CASTEiJ_G0019319
protein coding gene Chr12:97886656-98031872 (+)
CBA/J MGP_CBAJ_G0019745
protein coding gene Chr12:110945262-111104877 (+)
DBA/2J MGP_DBA2J_G0019856
protein coding gene Chr12:99282327-99424662 (+)
FVB/NJ MGP_FVBNJ_G0019845
protein coding gene Chr12:98009475-98150980 (+)
LP/J MGP_LPJ_G0019932
protein coding gene Chr12:103599585-103746958 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019885
protein coding gene Chr12:114431727-114581712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020449
protein coding gene Chr12:102107204-102249784 (+)
PWK/PhJ MGP_PWKPhJ_G0019082
protein coding gene Chr12:93838483-93978834 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018878
protein coding gene Chr12:96279842-96425219 (+)
WSB/EiJ MGP_WSBEiJ_G0019373
protein coding gene Chr12:102992279-103135766 (+)



Homology
more
  • Human Ortholog
    SLC24A4, solute carrier family 24 member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC24A4, solute carrier family 24 member 4
  • Synonyms
    AI2A5, NCKX4, SHEP6, SLC24A2
  • Links
    NCBI Gene ID: 123041
    neXtProt AC: NX_Q8NFF2
    UniProt: Q8NFF2

  • Chr Location
    14q32.12; chr14:92322581-92501481 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human SLC24A4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired olfactory response and reduced weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041771 Ensembl Gene Model | MGI Sequence Detail 138359 C57BL/6J ±  kb
    transcript ENSMUST00000079020 Ensembl | MGI Sequence Detail 2337 Not Applicable  
    polypeptide ENSMUSP00000078030 Ensembl | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015001 sodium/potassium/calcium exchanger 4
    • InterPro Domains
      IPR044880 NCX, central ion-binding domain superfamily
      IPR004837 Sodium/calcium exchanger membrane region
      IPR004481 Sodium/potassium/calcium exchanger
    • GlyGen
      Q8CGQ8 2 sites, 3 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145028, MGI:2443586
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 16
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory