Cmtm5 MGI Mouse Gene Detail - MGI:2447164 - CKLF-like MARVEL transmembrane domain containing 5

Symbol

Cmtm5
Name

CKLF-like MARVEL transmembrane domain containing 5
Synonyms

1500005P16Rik, 2900052H21Rik, Cklfsf5

Feature Type

protein coding gene
IDs

MGI:2447164
NCBI Gene: 67272
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55173927-55176734 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.00 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

73 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447164	protein coding gene	Chr14:55173718-55176734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021333	protein coding gene	Chr14:48919359-48921935 (+)
A/J	MGP_AJ_G0021292	protein coding gene	Chr14:47954143-47956719 (+)
AKR/J	MGP_AKRJ_G0021268	protein coding gene	Chr14:49699206-49701782 (+)
BALB/cJ	MGP_BALBcJ_G0021296	protein coding gene	Chr14:47931581-47934157 (+)
C3H/HeJ	MGP_C3HHeJ_G0021076	protein coding gene	Chr14:49392862-49395438 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021734	protein coding gene	Chr14:51390100-51394056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019281	protein coding gene	Chr14:46367704-46370286 (+)
CAST/EiJ	MGP_CASTEiJ_G0020595	protein coding gene	Chr14:45632048-45634626 (+)
CBA/J	MGP_CBAJ_G0021043	protein coding gene	Chr14:52949119-52951695 (+)
DBA/2J	MGP_DBA2J_G0021164	protein coding gene	Chr14:47696150-47698726 (+)
FVB/NJ	MGP_FVBNJ_G0021146	protein coding gene	Chr14:47154890-47157466 (+)
LP/J	MGP_LPJ_G0021238	protein coding gene	Chr14:49938773-49941349 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021170	protein coding gene	Chr14:52333615-52336191 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021761	protein coding gene	Chr14:48876664-48879240 (+)
PWK/PhJ	MGP_PWKPhJ_G0020342	protein coding gene	Chr14:44231048-44233624 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020170	protein coding gene	Chr14:44861541-44864121 (+)
WSB/EiJ	MGP_WSBEiJ_G0020648	protein coding gene	Chr14:49174129-49176705 (+)

Human Ortholog

CMTM5, CKLF like MARVEL transmembrane domain containing 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CMTM5, CKLF like MARVEL transmembrane domain containing 5
Synonyms

CKLFSF5
Links

HGNC:19176

NCBI Gene ID: 116173

neXtProt AC: NX_Q96DZ9

UniProt: Q96DZ9
Chr Location

14q11.2; chr14:23376439-23379772 (+) GRCh38.p7

Alliance of Genome Resources

Cmtm5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CMTM5
Gene Tree

Cmtm5

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Cmtm5
Find Mice (IMSR)

12 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit early-onset progressive axonopathy.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

831
Tissues

57
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cmtm5

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Cmtm5 interacts with 27 markers (Mir15a, Mir16-1, Mir16-2, ...) View All

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS27105.1, CCDS88667.1

Ensembl

ENSMUSG00000040759 (Evidence)
NCBI Gene

67272

			Length	Strain/Species	Flank
genomic	67272	NCBI Gene Model \| MGI Sequence Detail	2808	C57BL/6J	± kb
transcript	NM_026066	RefSeq \| MGI Sequence Detail	890	C57BL/6
polypeptide	Q9D6G9	UniProt \| EBI \| MGI Sequence Detail	156	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030970 CKLF-like MARVEL transmembrane domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:1914522, MGI:1922949

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:327261 Buscham TJ, et al., Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5. Elife. 2022 Mar 11;11:e75523

TSS for Cmtm5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125682	Chr14:55173696-55173760 (+)	-199 bp
Tssr125683	Chr14:55173913-55173935 (+)	-3 bp
Tssr125684	Chr14:55173937-55173991 (+)	37 bp
Tssr125685	Chr14:55175196-55175206 (+)	1,274 bp
Tssr125686	Chr14:55175212-55175242 (+)	1,300 bp
Tssr125687	Chr14:55175276-55175285 (+)	1,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 03/21/2023 MGI 6.22