Map3k7cl MGI Mouse Gene Detail - MGI:2446584

Symbol

Map3k7cl
Name

Map3k7 C-terminal like
Synonyms

ORF63

Feature Type

protein coding gene
IDs

MGI:2446584
NCBI Gene: 224419
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:87350218-87392224 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 49.58 cM
Mapping Data

1 experiment

SNPs within 2kb

437 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446584	protein coding gene	Chr16:87350208-87392224 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022980	protein coding gene	Chr16:88276359-88322786 (+)
A/J	MGP_AJ_G0022948	protein coding gene	Chr16:84204495-84248460 (+)
AKR/J	MGP_AKRJ_G0022918	protein coding gene	Chr16:86772192-86815273 (+)
BALB/cJ	MGP_BALBcJ_G0022950	protein coding gene	Chr16:84733276-84776740 (+)
C3H/HeJ	MGP_C3HHeJ_G0022712	protein coding gene	Chr16:87331758-87376318 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023397	protein coding gene	Chr16:91141928-91185262 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020901	protein coding gene	Chr16:82059141-82097324 (+)
CAST/EiJ	MGP_CASTEiJ_G0022234	protein coding gene	Chr16:87709020-87754412 (+)
CBA/J	MGP_CBAJ_G0022681	protein coding gene	Chr16:95052612-95101305 (+)
DBA/2J	MGP_DBA2J_G0022815	protein coding gene	Chr16:84129884-84172021 (+)
FVB/NJ	MGP_FVBNJ_G0022790	protein coding gene	Chr16:83235590-83279556 (+)
LP/J	MGP_LPJ_G0022884	protein coding gene	Chr16:87959621-88008047 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022809	protein coding gene	Chr16:99605655-99658477 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023415	protein coding gene	Chr16:87241980-87286674 (+)
PWK/PhJ	MGP_PWKPhJ_G0021977	protein coding gene	Chr16:84245198-84290743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021807	protein coding gene	Chr16:86769428-86812413 (+)
WSB/EiJ	MGP_WSBEiJ_G0022282	protein coding gene	Chr16:87469656-87517183 (+)

Human Ortholog

MAP3K7CL, MAP3K7 C-terminal like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K7CL, MAP3K7 C-terminal like
Synonyms

C21orf7, HC21ORF7, TAK1L, TAKL, TAKL-1, TAKL-2, TAKL-4
Links

HGNC:16457

NCBI Gene ID: 56911

neXtProt AC: NX_P57077

UniProt: P57077
Chr Location

21q21.3; chr21:29077114-29175889 (+) GRCh38

MGI Vertebrate Homology

Map3k7cl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K7CL
Gene Tree

Map3k7cl

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References

1 with disease annotations

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Phenotype Summary

19 phenotype references

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

4 involving Map3k7cl
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

864
Tissues

132
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

6
UniProt

2
CCDS

CCDS28292.1

Ensembl

ENSMUSG00000025610 (Evidence)
NCBI Gene

224419

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025610	Ensembl Gene Model \| MGI Sequence Detail	42007	C57BL/6J	± kb
transcript	ENSMUST00000026700	Ensembl \| MGI Sequence Detail	1652	Not Applicable
polypeptide	ENSMUSP00000026700	Ensembl \| MGI Sequence Detail	142	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016042 MAP3K7 C-terminal-like protein

(term hierarchy)
InterPro Domains

IPR042800 MAP3K7 C-terminal-like protein

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 4

Diseases 1

Gene Ontology 1

Phenotypes 19
Earliest

J:76842 Reymond A, et al., From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Genomics. 2001 Nov;78(1-2):46-54
Latest

J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883

TSS for Map3k7cl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139222	Chr16:87350201-87350230 (+)	-2 bp
Tssr139223	Chr16:87350290-87350301 (+)	78 bp
Tssr139224	Chr16:87350303-87350360 (+)	114 bp
Tssr139225	Chr16:87350405-87350418 (+)	194 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23