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Tpte Gene Detail
Summary
  • Symbol
    Tpte
  • Name
    transmembrane phosphatase with tensin homology
  • Synonyms
    Pten2, Vsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446460
    NCBI Gene: 234129
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22773457-22861432 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446460
protein coding gene Chr8:22773457-22861434 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033449
protein coding gene Chr8:20129590-20219198 (+)
A/J MGP_AJ_G0033429
protein coding gene Chr8:19476636-19562837 (+)
AKR/J MGP_AKRJ_G0033354
protein coding gene Chr8:20110790-20197113 (+)
BALB/cJ MGP_BALBcJ_G0033425
protein coding gene Chr8:19600398-19687795 (+)
C3H/HeJ MGP_C3HHeJ_G0033139
protein coding gene Chr8:20314300-20402112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033941
protein coding gene Chr8:20988616-21080529 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032465
protein coding gene Chr8:19729049-19822146 (+)
CBA/J MGP_CBAJ_G0033114
protein coding gene Chr8:21830960-21919139 (+)
DBA/2J MGP_DBA2J_G0033269
protein coding gene Chr8:19447543-19532076 (+)
FVB/NJ MGP_FVBNJ_G0033213
protein coding gene Chr8:19241437-19326283 (+)
LP/J MGP_LPJ_G0033358
protein coding gene Chr8:20131419-20220346 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033256
protein coding gene Chr8:21420345-21511620 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033960
protein coding gene Chr8:20016920-20104310 (+)
PWK/PhJ MGP_PWKPhJ_G0032177
protein coding gene Chr8:19033346-19117685 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032010
protein coding gene Chr8:19405328-19504305 (+)
WSB/EiJ MGP_WSBEiJ_G0032581
protein coding gene Chr8:20222981-20314299 (+)



Homology
more
  • Human Ortholog
    TPTE, transmembrane phosphatase with tensin homology
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPTE, transmembrane phosphatase with tensin homology
  • Synonyms
    CT44, PTEN2, TPTE1
  • Links
    NCBI Gene ID: 7179
    neXtProt AC: NX_P56180
    UniProt: P56180

  • Chr Location
    21p11.2; chr21:10521553-10606140 (+)  GRCh38

  • Human Ortholog
    TPTE2, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  • Synonyms
    TPIP
  • Links
    NCBI Gene ID: 93492
    neXtProt AC: NX_Q6XPS3
    UniProt: Q6XPS3

  • Chr Location
    13q12.11; chr13:19422876-19561625 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele exhibit impaired fertilization associated with loss of sperm midpiece flexibility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234129 NCBI Gene Model | MGI Sequence Detail 87976 C57BL/6J ±  kb
    transcript NM_199257 RefSeq | MGI Sequence Detail 2547 C57BL/6  
    polypeptide NP_954866 RefSeq | MGI Sequence Detail 664 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR035892 C2 domain superfamily
      IPR005821 Ion transport domain
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR029021 Protein-tyrosine phosphatase-like
      IPR014020 Tensin phosphatase, C2 domain
      IPR029023 Tensin-type phosphatase domain
      IPR045102 TPTE, protein tyrosine phosphatase-like catalytic domain
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
      IPR027359 Voltage-dependent channel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:73952 Guipponi M, et al., The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. Hum Genet. 2001 Dec;109(6):569-75
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory