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Sbsn Gene Detail
Summary
  • Symbol
    Sbsn
  • Name
    suprabasin
  • Synonyms
    1110005D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446326
    NCBI Gene: 282619
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30450896-30455559 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446326
 protein coding gene Chr7:30432099-30455559 (+)
129S1/SvImJ ENSMUSG00200022257
 protein coding gene Chr7:20219691-20224416 (+)
A/J ENSMUSG00195047814
 protein coding gene Chr7:22895964-22900681 (+)
AKR/J ENSMUSG00220052629
 protein coding gene Chr7:21577818-21582543 (-)
BALB/cJ ENSMUSG00180016821
 protein coding gene Chr7:20955430-20960149 (+)
C3H/HeJ ENSMUSG00175038304
 protein coding gene Chr7:22039927-22044590 (+)
C57BL/6NJ ENSMUSG00215017904
 protein coding gene Chr7:20142076-20146741 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029543
 protein coding gene Chr7:29956580-29978133 (+)
CAST/EiJ ENSTCUG00005047571
 protein coding gene Chr7:21932503-21937405 (+)
CBA/J ENSMUSG00210026560
 protein coding gene Chr7:21202550-21207215 (+)
DBA/2J ENSMUSG00185049835
 protein coding gene Chr7:24285803-24290824 (+)
FVB/NJ ENSMUSG00205015157
 protein coding gene Chr7:20951895-20956558 (+)
JF1/MsJ ENSUMUG00000056066
 protein coding gene Chr7:28727194-28732219 (+)
LP/J ENSMUSG00230052544
 protein coding gene Chr7:29451774-29456493 (+)
NOD/ShiLtJ ENSMUSG00190008004
 protein coding gene Chr7:20620316-20625033 (+)
NZO/HlLtJ ENSMUSG00225024315
 protein coding gene Chr7:28292453-28297474 (+)
PWK/PhJ ENSLUMG00010020076
 protein coding gene Chr7:20659391-20664328 (+)
SPRET/EiJ ENSMSPG00010048581
 protein coding gene Chr7:20018416-20023317 (+)
WSB/EiJ ENSIUOG00005049685
 protein coding gene Chr7:14903967-14908682 (+)



Homology
more
  • Human Ortholog
    SBSN, suprabasin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SBSN, suprabasin
  • Synonyms
    UNQ698
  • Links
    NCBI Gene ID: 374897
    UniProt: Q6UWP8

  • Chr Location
    19q13.12; chr19:35523367-35528351 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired embryo barrier function in embryos; scarce, immature, and fragile stratum corneum; increased nickel serum levels following loading; and increased contact hypersensitivity in response to nickel loading.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    31
  • cDNA Data
    58
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046056 Ensembl Gene Model | MGI Sequence Detail 4664 C57BL/6J ±  kb
    transcript ENSMUST00000080518 Ensembl | MGI Sequence Detail 2221 Not Applicable  
    polypeptide ENSMUSP00000079362 Ensembl | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920983, MGI:2142027
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 7
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory