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Spire2 Gene Detail
Summary
  • Symbol
    Spire2
  • Name
    spire type actin nucleation factor 2
  • Synonyms
    MGC:31610, Spir-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446256
    NCBI Gene: 234857
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124059452-124096254 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1417 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446256
 protein coding gene Chr8:124059452-124096257 (+)
129S1/SvImJ ENSMUSG00200041675
 protein coding gene Chr8:118387919-118424742 (+)
A/J ENSMUSG00195025826
 protein coding gene Chr8:118681505-118718304 (+)
AKR/J ENSMUSG00220038818
 protein coding gene Chr8:118877116-118913818 (+)
BALB/cJ ENSMUSG00180023910
 protein coding gene Chr8:118727489-118764286 (+)
C3H/HeJ ENSMUSG00175030735
 protein coding gene Chr8:118789029-118825729 (+)
C57BL/6NJ ENSMUSG00215026778
 protein coding gene Chr8:118365757-118402558 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031687
 protein coding gene Chr8:114502125-114540194 (+)
CAST/EiJ ENSTCUG00005034192
 protein coding gene Chr8:118104145-118141191 (+)
CBA/J ENSMUSG00210032579
 protein coding gene Chr8:118716212-118752831 (+)
DBA/2J ENSMUSG00185033835
 protein coding gene Chr8:124821153-124857768 (+)
FVB/NJ ENSMUSG00205026862
 protein coding gene Chr8:117684431-117721232 (+)
JF1/MsJ ENSUMUG00000018592
 protein coding gene Chr8:127120624-127157423 (+)
LP/J ENSMUSG00230028655
 protein coding gene Chr8:128439317-128476138 (+)
NOD/ShiLtJ ENSMUSG00190018458
 protein coding gene Chr8:118818673-118855468 (+)
NZO/HlLtJ ENSMUSG00225042690
 protein coding gene Chr8:131823545-131860339 (+)
PWK/PhJ ENSLUMG00010032251
 protein coding gene Chr8:118525415-118562116 (+)
SPRET/EiJ ENSMSPG00010037202
 protein coding gene Chr8:120714930-120751762 (+)
WSB/EiJ ENSIUOG00005027677
 protein coding gene Chr8:119503181-119540142 (+)



Homology
more
  • Human Ortholog
    SPIRE2, spire type actin nucleation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPIRE2, spire type actin nucleation factor 2
  • Synonyms
    Spir-2
  • Links
    NCBI Gene ID: 84501
    UniProt: Q8WWL2

  • Chr Location
    16q24.3; chr16:89818179-89871319 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    94
  • cDNA Data
    14
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010154 Ensembl Gene Model | MGI Sequence Detail 36803 C57BL/6J ±  kb
transcript ENSMUST00000010298 Ensembl | MGI Sequence Detail 2330 Not Applicable  
polypeptide ENSMUSP00000010298 Ensembl | MGI Sequence Detail 718 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:89167 Schumacher N, et al., Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain. Gene Expr Patterns. 2004 May;4(3):249-55
  • Latest
    J:282947 Poncet N, et al., Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. EMBO Rep. 2020 Jan 7;21(1):e48469
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory