Cracr2b MGI Mouse Gene Detail - MGI:2446129 - calcium release activated channel regulator 2B

Symbol

Cracr2b
Name

calcium release activated channel regulator 2B
Synonyms

6330520A15Rik, Efcab4a

Feature Type

protein coding gene
IDs

MGI:2446129
NCBI Gene: 213573
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:141041007-141046526 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.82 cM
Mapping Data

2 experiments

SNPs within 2kb

187 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446129	protein coding gene	Chr7:141041007-141046526 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033233	protein coding gene	Chr7:146652396-146659524 (+)
A/J	MGP_AJ_G0033215	protein coding gene	Chr7:142458052-142464676 (+)
AKR/J	MGP_AKRJ_G0033147	protein coding gene	Chr7:146410110-146415626 (+)
BALB/cJ	MGP_BALBcJ_G0033216	protein coding gene	Chr7:142203560-142209102 (+)
C3H/HeJ	MGP_C3HHeJ_G0032930	protein coding gene	Chr7:146145507-146151019 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033727	protein coding gene	Chr7:152005228-152010683 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030700	protein coding gene	Chr7:143666306-143671925 (+)
CAST/EiJ	MGP_CASTEiJ_G0032260	protein coding gene	Chr7:138458248-138465024 (+)
CBA/J	MGP_CBAJ_G0032902	protein coding gene	Chr7:157164973-157170489 (+)
DBA/2J	MGP_DBA2J_G0033054	protein coding gene	Chr7:140403543-140409060 (+)
FVB/NJ	MGP_FVBNJ_G0033007	protein coding gene	Chr7:140317821-140323974 (+)
LP/J	MGP_LPJ_G0033149	protein coding gene	Chr7:148146480-148152012 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033040	protein coding gene	Chr7:157798135-157804817 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033747	protein coding gene	Chr7:145367913-145373424 (+)
PWK/PhJ	MGP_PWKPhJ_G0031964	protein coding gene	Chr7:133688662-133694191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031811	protein coding gene	Chr7:132201797-132207337 (+)
WSB/EiJ	MGP_WSBEiJ_G0032371	protein coding gene	Chr7:146316357-146321970 (+)

Human Ortholog

CRACR2B, calcium release activated channel regulator 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRACR2B, calcium release activated channel regulator 2B
Synonyms

EFCAB4A
Links

HGNC:28703

NCBI Gene ID: 283229

UniProt: Q8N4Y2
Chr Location

11p15.5; chr11:826144-831991 (+) GRCh38

MGI Vertebrate Homology

Cracr2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRACR2B
Gene Tree

Cracr2b

less

Phenotype Summary

6 phenotype references

All Mutations and Alleles

5
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Cracr2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

less

All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

38

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cracr2b

less

All Sequences

56
RefSeq

8
UniProt

7
CCDS

CCDS22016.1

Ensembl

ENSMUSG00000048200 (Evidence)
NCBI Gene

213573

			Length	Strain/Species	Flank
genomic	213573	NCBI Gene Model \| MGI Sequence Detail	5520	C57BL/6J	± kb
transcript	NM_001025103	RefSeq \| MGI Sequence Detail	1687	Not Specified
polypeptide	Q80ZJ8	UniProt \| EBI \| MGI Sequence Detail	394	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000032227 EF-hand calcium-binding domain-containing protein 4A

(term hierarchy)
InterPro Domains

IPR051111 Calcium-binding regulatory protein

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

less

All nucleic 38

cDNA 38

Microarray probesets 2

less

MGI:1925677

Summaries

All 30

Gene Ontology 2

Phenotypes 6
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Cracr2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69973	Chr7:141039129-141039143 (+)	-1,871 bp
Tssr69974	Chr7:141039313-141039322 (+)	-1,689 bp
Tssr69975	Chr7:141039410-141039423 (+)	-1,590 bp
Tssr69976	Chr7:141039430-141039442 (+)	-1,571 bp
Tssr69977	Chr7:141039523-141039539 (+)	-1,476 bp
Tssr69978	Chr7:141039554-141039577 (+)	-1,441 bp
Tssr69979	Chr7:141039599-141039608 (+)	-1,403 bp
Tssr69980	Chr7:141039801-141039833 (+)	-1,190 bp
Tssr69981	Chr7:141040835-141040864 (+)	-157 bp
Tssr69982	Chr7:141040897-141040921 (+)	-98 bp
Tssr69983	Chr7:141040988-141041014 (+)	-6 bp
Tssr69984	Chr7:141041018-141041050 (+)	27 bp
Tssr69985	Chr7:141041641-141041670 (+)	649 bp
Tssr69986	Chr7:141042634-141042636 (+)	1,628 bp
Tssr69987	Chr7:141043942-141044002 (+)	2,965 bp
Tssr69988	Chr7:141044006-141044026 (+)	3,009 bp
Tssr69989	Chr7:141045012-141045046 (+)	4,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24