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Hace1 Gene Detail
Summary
  • Symbol
    Hace1
  • Name
    HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
  • Synonyms
    1700042J16Rik, A730034A22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446110
    NCBI Gene: 209462
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:45453925-45588441 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 23.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446110
protein coding gene Chr10:45453911-45588441 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017210
protein coding gene Chr10:44473467-44610025 (+)
A/J MGP_AJ_G0017186
protein coding gene Chr10:43219298-43353284 (+)
AKR/J MGP_AKRJ_G0017145
protein coding gene Chr10:43919137-44057193 (+)
BALB/cJ MGP_BALBcJ_G0017147
protein coding gene Chr10:43275668-43402972 (+)
C3H/HeJ MGP_C3HHeJ_G0016971
protein coding gene Chr10:44210320-44350529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017605
protein coding gene Chr10:45839881-45991038 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015300
protein coding gene Chr10:41087875-41213399 (+)
CAST/EiJ MGP_CASTEiJ_G0016545
protein coding gene Chr10:44475686-44611385 (+)
CBA/J MGP_CBAJ_G0016942
protein coding gene Chr10:47877069-48034569 (+)
DBA/2J MGP_DBA2J_G0017047
protein coding gene Chr10:42639102-42774811 (+)
FVB/NJ MGP_FVBNJ_G0017041
protein coding gene Chr10:42139222-42267414 (+)
LP/J MGP_LPJ_G0017122
protein coding gene Chr10:44508455-44650635 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017070
protein coding gene Chr10:48545680-48720980 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017641
protein coding gene Chr10:43905972-44044370 (+)
PWK/PhJ MGP_PWKPhJ_G0016324
protein coding gene Chr10:42599074-42726960 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016109
protein coding gene Chr10:43689894-43829807 (+)
WSB/EiJ MGP_WSBEiJ_G0016608
protein coding gene Chr10:44140699-44274434 (+)



Homology
more
  • Human Ortholog
    HACE1, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HACE1, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  • Synonyms
    SPPRS
  • Links
    NCBI Gene ID: 57531
    neXtProt AC: NX_Q8IYU2
    UniProt: Q8IYU2

  • Chr Location
    6q16.3; chr6:104728094-104859919 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased spontaneous and induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038822 Ensembl Gene Model | MGI Sequence Detail 134517 C57BL/6J ±  kb
    transcript ENSMUST00000037044 Ensembl | MGI Sequence Detail 3785 Not Applicable  
    polypeptide ENSMUSP00000039206 Ensembl | MGI Sequence Detail 909 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920541, MGI:2444231
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:343275 Turgu B, et al., The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. EMBO Rep. 2023 Dec 6;24(12):e56815

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory